Abstract
The temporal pattern of changes in energy balance and cytokine mRNA expression in spleen and brain were examined in a mouse model of infection with Toxoplasma gondii. During days 1-7 postinfection, food intake was unaltered, but energy expenditure was significantly increased, and this was associated with elevated tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1, IL-5, and interferon (IFN)-gamma. The hypermetabolic state persisted during subsequent anorexia, whose onset coincided with elevated IL-2, and at the end of the acute phase of cachexia, the dual anorexic and hypermetabolic states were associated with the cytokines examined: TNF-alpha, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-10, and IFN-gamma. In the chronic phase of the infection, the mice showed either partial weight recovery (gainers) or no weight regain (nongainers). The infected gainers, though still hypophagic, were no longer hypermetabolic, and their cytokine mRNA was no longer elevated, except for TNF-alpha and IL-10. In contrast, the infected nongainers continued to show both anoroxia and hypermetabolism, which were associated with elevations in all cytokines examined and particularly those of the TH2 profile (IL-4 and IL-5) and IL-6. Taken together, th...Continue Reading
References
Nov 27, 1979·Biochemistry·J M ChirgwinW J Rutter
Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·B R BistrianN W Istfan
Jul 1, 1992·The American Journal of Tropical Medicine and Hygiene·K J Tracey, A Cerami
Jul 1, 1991·The Journal of Infectious Diseases·J Huskinson-MarkJ S Remington
Jan 1, 1990·European Journal of Immunology·L J MurrayC Martens
Apr 15, 1991·Cellular Immunology·R KellerF H Kayser
Sep 1, 1990·The American Journal of Clinical Nutrition·A G Dulloo, L Girardier
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D CaputA Cerami
Sep 1, 1989·Brain, Behavior, and Immunity·C R Plata-Salaman
Feb 1, 1988·Annals of Tropical Medicine and Parasitology·W Stahl, G Turek
Dec 1, 1984·The Journal of Infectious Diseases·R E McCabeJ S Remington
Jun 1, 1995·Current Opinion in Immunology·S L Reiner, R A Seder
Nov 1, 1995·The Journal of Clinical Investigation·D J BergD Rennick
Jul 1, 1994·Infection and Immunity·Y SuzukiJ S Remington
Jan 1, 1959·The British Journal of Nutrition·D S MILLER, P R PAYNE
Citations
Feb 17, 2005·American Journal of Physiology. Endocrinology and Metabolism·Denis ArsenijevicWolfgang Langhans
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Frédéric PicardYves Deshaies
Jun 28, 2019·Frontiers in Cellular and Infection Microbiology·Stephanie J Melchor, Sarah E Ewald
Jun 8, 2001·Parasitology·J HavlícekJ Flegr
Jul 30, 2015·Neural Plasticity·Ian A Clark, Bryce Vissel
May 6, 2015·British Journal of Pharmacology·I A Clark, B Vissel