Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery.

Journal of the European Academy of Dermatology and Venereology : JEADV
T GambichlerL Schmitz

Abstract

Koebnerized non-melanoma skin cancer following skin trauma represents a rare and obscure event. To study molecular pathological parameters in koebnerized squamous cell carcinomas (K-SCCs) occurring after complete tumour removal. We assessed two patients with multiple sclerosis who were on treatment with dimethylfumarate (DMF) preceded by long-term azathioprine therapy. Both patients rapidly developed several K-SCCs following histopathologically proven complete excision of cutaneous SCCs. We performed immunohistochemistry for p53, p16, Ki-67, TET-2, IDH-2, 5-hmc and 5-mc. PCR was carried out for the detection of human papilloma viruses. Mutation analysis was performed for BRAF, K-RAS and EGFR. All lesions investigated were negative for HPV DNA. Mutations were not detected. Healthy appearing skin of both patients showed relatively high Ki-67, p16 and p53 expression which was comparable to the expression observed in primary SCCs as well as K-SCCs. Protein expression of Ki-67, p16 and mutant p53 was barely detected in the specimens of the healthy controls. A decreased protein expression of TET-2 enzyme was seen in all tumours and healthy appearing skin when compared to the skin of healthy controls. We observed two patients with K-S...Continue Reading

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Citations

Jan 27, 2019·Experimental and Therapeutic Medicine·Bianca MihăilăOlimpia Dumitriu Buzia
May 26, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·T Gambichler, L Schmitz
Aug 7, 2019·Experimental and Therapeutic Medicine·Alin Laurentiu TatuLawrence Chukwudi Nwabudike
Feb 26, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Samsul ArefinPeter Stenvinkel

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