PMID: 8605222Feb 9, 1996Paper

Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis

Biochimica Et Biophysica Acta
K HottaY Matsuzawa

Abstract

We conducted a quantitative study of the effect of carnitine deficiency on the mRNA level of carnitine palmitoyltransferase II in the liver, muscle and heart of mice with juvenile visceral steatosis, a strain that is systematically deficient in carnitine. The amount of carnitine palmitoyltransferase II mRNA was increased in liver and muscle of homozygotes, as compared with heterozygotes and normal controls, at 2, 4, and 8 wk of age. The mRNA levels of this enzyme were normalized after carnitine administration. The mRNA level of carnitine palmitoyltransferase II in the heart was increased only at 8 wk, and was not affected by carnitine administration. These results suggest that carnitine displays some effect on the mRNA level of the carnitine palmitoyltransferase II gene in liver and muscle, probably through fatty acid metabolic change.

References

Feb 14, 1992·Biochimica Et Biophysica Acta·M TomomuraT Saheki
Dec 5, 1991·European Journal of Biochemistry·K HottaS Tarui
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G FinocchiaroS DiDonato
Jan 1, 1986·Annual Review of Nutrition·C J Rebouche, D J Paulson
Jan 1, 1980·Annual Review of Biochemistry·J D McGarry, D W Foster

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