Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
T KudoK Sugiyama

Abstract

To investigate the pharmacokinetic characteristics in TSOD (Tsumura, Suzuki, obese, diabetes) mice, a model of type 2 diabetes and obesity, the expressions of major hepatic CYP enzymes in TSOD and TSNO (Tsumura, Suzuki, non-obesity; control) mice were compared. The 7-month-old TSOD mice, which represented severe obesity/diabetes-related pathophysiology, showed higher expressions of Cyp2c and Cyp3a compared with TSNO mice, while those of Cyp1a and Cyp2e were lower. Cyp3a metabolic activity was also higher in TSOD mice. In the 7-month-old liver, pregnane X receptor (PXR) (nuclear receptor) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) (cofactor) mRNA expression were higher in TSOD mice, possibly playing a role in the altered expression of Cyp3a. This specifically altered CYP expression in TSOD mice suggests that the biotransformation of drugs metabolized by these CYP enzymes differs from that in normal animals. Based on these findings, further investigation on the relationship between altered CYP expression and pathophysiology may be useful in elucidating changes in pharmacokinetics in obese/diabetic patients.

References

May 1, 1992·Clinical Pharmacology and Therapeutics·Y CaracoM Levy
Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno
Oct 1, 1994·The International Journal of Biochemistry·N Shimojo
May 19, 1998·Nutrition Reviews·B M Popkin, C M Doak
Mar 27, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A L RoeJ E Snawder
May 20, 1999·Diabetes·I HirayamaT Izumi
Feb 19, 2000·Biochemical and Biophysical Research Communications·I A LeclercqG R Robertson
Jul 24, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T SakumaN Nemoto
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy
Mar 22, 2002·The Journal of Biological Chemistry·Keith L LevertJacqueline M Stephens
Dec 17, 2002·European Journal of Clinical Pharmacology·Maria Paula MarquesVera Lucia Lanchote
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
May 25, 2004·Molecular Endocrinology·Christopher A WiwiDavid J Waxman
Feb 24, 2005·Experimental Animals·Seiichi IizukaKazuaki W Takahashi
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shin MizutaniTetsuro Izumi
May 23, 2006·Pharmaceutical Research·Kouichi YoshinariMasao Miwa
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Kouichi YoshinariMasao Miwa
Nov 17, 2006·Archives of Biochemistry and Biophysics·M J DownJ J Mills
Jan 15, 2008·Molecular Pharmaceutics·Qiuqiong ChengAngela L Slitt

❮ Previous
Next ❯

Citations

Oct 6, 2012·Biological & Pharmaceutical Bulletin·Shigeo MiyataTomie Kawada
Dec 10, 2013·Cell and Tissue Research·Fabio Quondamatteo
Jul 9, 2013·Bioscience, Biotechnology, and Biochemistry·Yuko ShimamuraShuichi Masuda
Feb 19, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T KudoK Sugiyama
Jan 30, 2016·Journal of Diabetes Research·Matej SamošMarián Mokáň
Dec 17, 2014·Pharmacology Research & Perspectives·Dany PatoineChantale Simard
Nov 3, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ali TaheriMohammad-Reza Rouini
Apr 22, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M ChenX D Liu
Apr 27, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Miaoran Ning, Hyunyoung Jeong
Dec 5, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Petra MatouškováLenka Skálová
Feb 20, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Joanna PorażkaEdmund Grześkowiak
Sep 27, 2018·Nature Reviews. Cardiology·Giuseppe PattiUNKNOWN Working Group on Thrombosis of the Italian Society of Cardiology
May 11, 2019·Current Diabetes Reviews·Anshul ShakyaSurajit Kumar Ghosh
Mar 15, 2018·International Journal of Molecular Sciences·Junjun WangYong Chen
Dec 31, 2019·Journal of Diabetes Research·Dana PrídavkováMarián Mokáň
Nov 5, 2020·Cells·Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Jul 13, 2021·European Journal of Pharmacology·Trang Thi Huyen DangJong Won Yun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.