Abstract
Hepatocyte growth factor (HGF)-related E-cadherin expression and prognosis of patients with nasopharyngeal carcinoma (NPC) are not fully understood. This study investigated HGF-induced altered expression of E-cadherin and the relationship between prognosis and modulation of E-cadherin by HGF in NPC. 135 cases of NPC were collected, and expression of HGF, c-Met, and E-cadherin in tissue microarray was evaluated by immunohistochemical staining. Correlation between immunostainings and clinicopathological parameters, as well as the follow-up data of patients, was analyzed statistically. The association and alteration of E-cadherin by HGF treatment in NPC cell lines were evaluated by immunocytochemical staining, Western blot, and invasion assay. Both high HGF expression in tumor cells (62.9%, 85/135 cases) and nonmembranous E-cadherin expression (61.5%, 83/135 cases) were significantly associated with advanced clinical stage, lymph node metastasis, and worse prognosis of NPC patients. However, only abnormal E-cadherin expression (P = 0.001) and lymph node metastasis (P = 0.004) emerged as strong independent prognostic factors for overall survival of NPC patients. In vitro, exogenous HGF decreased and internalized E-cadherin expressi...Continue Reading
References
Feb 4, 1995·Lancet·P Boros, C M Miller
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·A TannapfelE Tahara
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·H MinF Qiu
Jun 1, 1994·The Journal of Cell Biology·L HinckW J Nelson
Feb 9, 2000·The Journal of Cell Biology·B M Gumbiner
Mar 21, 2001·Human Molecular Genetics·O P KallioniemiG Sauter
Apr 11, 2001·International Journal of Oncology·M SteffenU Scherdin
Sep 5, 2001·The EMBO Journal·F PalaciosC D'Souza-Schorey
Dec 18, 2001·Urology·H MiuraA Okuyama
Jan 10, 2002·Oncogene·G LiM Herlyn
Jan 11, 2002·The Journal of Biological Chemistry·Zhen-Xiang LiuLloyd G Cantley
Mar 20, 2002·Cancer·Hsiao Wen ChangAnthonyPoWing Yuen
Nov 27, 2002·Seminars in Cancer Biology·Mimi C Yu, Jian-Min Yuan
Jul 23, 2003·Archives of Otolaryngology--head & Neck Surgery·Terence P FariasFernando B Gonçalves
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Carmen BirchmeierGeorge F Vande Woude
Jun 8, 2004·Cell Death and Differentiation·M KondoK Miyazono
Jul 19, 2005·Cancer Research·Erik W ThompsonDavid Tarin
Oct 26, 2005·Annals of Surgery·Sang-Uk HanKuhn Uk Lee
Feb 14, 2006·Endocrinology·Hong Y Zhou, Alice S T Wong
Jul 15, 2006·Carcinogenesis·Paola MaroniMaria Alfonsina Desiderio
Jul 22, 2006·The EMBO Journal·Stefan GrotegutFrançois Lehembre
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark R AndersonJanusz A Z Jankowski
Feb 13, 2007·Annals of Surgical Oncology·Chul-Ho KimEun Chang Choi
Mar 6, 2007·Cell Biology International·Galina ReshetnikovaDavid L Rimm
Jul 7, 2007·Molecular Biology of the Cell·Takuya ShirakiharaKohei Miyazono
Jul 24, 2007·Experimental Cell Research·Julie K SpixJes K Klarlund
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Mao YeJia Qu
May 3, 2008·Cancer Science·Erina NakamuraIssei Imoto
Jul 5, 2008·Clinical & Experimental Metastasis·Alan WellsChristopher R Shepard
Sep 16, 2008·FEBS Letters·Hong Yan ZhouAlice S T Wong
Nov 18, 2008·The Journal of Biological Chemistry·Kana HoriguchiMasao Saitoh
Mar 10, 2009·Pathology, Research and Practice·Zhi LiHui-Zhen Liang
Citations
Feb 25, 2014·Annals of Surgical Oncology·Bon Seok KooYoung Chang Lim
Jun 30, 2012·World Journal of Surgical Oncology·You-Feng GuoZhi Li
Jun 7, 2011·BMC Cancer·Gerhard F HuberSandro J Stoeckli
Sep 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuncheng LiWeijia Kong
Aug 26, 2011·Pathology Oncology Research : POR·Patrick C Lau, Elaine Y Wong
Jun 14, 2013·Journal of Translational Medicine·Li-na LiuBo-hang Zeng
Apr 22, 2015·Molecular Medicine Reports·Chao-Pan ZhengWei-Ping Wen
May 3, 2014·Pharmacology & Therapeutics·Lluís NisaMichaela Medová
Sep 17, 2013·Cell Proliferation·N M AyoubP W Sylvester
Jan 11, 2012·Journal of Surgical Oncology·Yin LiWen-Hua Zan
Feb 5, 2013·Human Pathology·Lina XuSongqing Fan
Jun 24, 2014·Oncogene·B S KooY C Lim
May 8, 2014·Biochemical and Biophysical Research Communications·Tongxin LiuWei Wang
Jul 21, 2012·PloS One·Chunfang HuJohn R Arrand
Jan 17, 2013·Korean Journal of Pathology·Ji-Young ChoeJi Eun Kim
Jul 12, 2012·Oncology Letters·Rui SunJian Sun
May 13, 2015·Oncotarget·Yingqin LiJun Ma
Jul 12, 2018·Cancer Biomarkers : Section a of Disease Markers·Jin-Zhang ChengDan Yu
Dec 12, 2012·International Journal of Oncology·Toshiyuki TanahashiKazuhiro Yoshida
Jul 15, 2018·Molecular Diagnosis & Therapy·Javad YazdaniFarzin Ahmadpour