Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma

Annals of Surgical Oncology
Li-qiong XieBin Li

Abstract

Hepatocyte growth factor (HGF)-related E-cadherin expression and prognosis of patients with nasopharyngeal carcinoma (NPC) are not fully understood. This study investigated HGF-induced altered expression of E-cadherin and the relationship between prognosis and modulation of E-cadherin by HGF in NPC. 135 cases of NPC were collected, and expression of HGF, c-Met, and E-cadherin in tissue microarray was evaluated by immunohistochemical staining. Correlation between immunostainings and clinicopathological parameters, as well as the follow-up data of patients, was analyzed statistically. The association and alteration of E-cadherin by HGF treatment in NPC cell lines were evaluated by immunocytochemical staining, Western blot, and invasion assay. Both high HGF expression in tumor cells (62.9%, 85/135 cases) and nonmembranous E-cadherin expression (61.5%, 83/135 cases) were significantly associated with advanced clinical stage, lymph node metastasis, and worse prognosis of NPC patients. However, only abnormal E-cadherin expression (P = 0.001) and lymph node metastasis (P = 0.004) emerged as strong independent prognostic factors for overall survival of NPC patients. In vitro, exogenous HGF decreased and internalized E-cadherin expressi...Continue Reading

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Citations

Sep 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuncheng LiWeijia Kong
Aug 26, 2011·Pathology Oncology Research : POR·Patrick C Lau, Elaine Y Wong
Jun 14, 2013·Journal of Translational Medicine·Li-na LiuBo-hang Zeng
Apr 22, 2015·Molecular Medicine Reports·Chao-Pan ZhengWei-Ping Wen
May 3, 2014·Pharmacology & Therapeutics·Lluís NisaMichaela Medová

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