PMID: 9655251Jul 9, 1998Paper

Altered expression of epidermal growth factor receptor ligands in tumor promoter-treated mouse epidermis and in primary mouse skin tumors induced by an initiation-promotion protocol

Molecular Carcinogenesis
K KiguchiJohn Digiovanni

Abstract

Multiple epidermal growth factor receptor (EGFr) ligands have been identified, including transforming growth factor alpha (TGFalpha), heparin-binding epidermal growth factor (HB-EGF), amphiregulin (AR), and betacellulin (BTC). Previous work from our laboratory demonstrated that TGFalpha mRNA and protein are upregulated in epidermis during tumor-promoter treatment of mouse skin and in skin tumors produced by initiation-promotion regimens. The purpose of the study described here was to explore the role of other EGFr ligands in multistage skin carcinogenesis. A single topical treatment of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or chrysarobin or a single full-thickness wound induced the expression of HB-EGF and AR in mRNA samples isolated from whole mouse skin. However, only full-thickness wounding significantly elevated expression of the BTC transcript. The levels of HB-EGF and AR transcripts were significantly elevated in skin tumors (both papillomas and squamous cell carcinomas) induced by initiation-promotion protocols. BTC transcript levels were low and barely detectable in all skin tumors examined. The level of keratinocyte growth factor (KGF) mRNA was also examined as a possible mechanism for upregulation of EGFr ...Continue Reading

Citations

Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·P TuohimaaT Ylikomi
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·A J Dunbar, C Goddard
Jan 22, 2009·Cancer Research·Ann M BodeZigang Dong
Oct 26, 2007·The Journal of Investigative Dermatology·Marlon R SchneiderSabine Werner
Jul 22, 2010·Molecular Carcinogenesis·Okkyung RhoJohn Digiovanni
Jan 27, 2011·Molecular Carcinogenesis·Inok SurhSusan M Fischer
Nov 12, 2014·PloS One·Manuel CorreiaMaria Teresa Neves-Petersen
Jan 28, 2014·Carcinogenesis·Amrish SharmaPatricia S Lorenzo

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