Altered expression of extracellular matrix proteins and integrins in oral lichen planus (OLP)

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
J Becker, D Schuppan

Abstract

The immunohistochemical distribution of collagens type I, III, IV, V, VI, of undulin and tenascin, and of integrins alpha 2, alpha 3, alpha 4, alpha 5, alpha 6 and beta 4, was studied in 14 biopsies of oral lichen planus (OLP), 5 biopsies of orthokeratinized gingiva and 4 biopsies of oral fibrous hyperplasia. The localization of extracellular matrix proteins showed altered expression in OLP when compared to normal oral mucosa, with two principal patterns corresponding to the reticular or atrophic type. Whereas in the reticular type a focal loss of immunoreactivity for collagen types I, III, V, VI and undulin was noted in areas with a cellular infiltrate, in the atrophic variant almost complete loss of immunoreactivity of the subepithelial extracellular matrix was found. There was no clear correlation between the distribution of extracellular matrix proteins and their integrin receptors. The present findings suggest that the autoimmune reaction in OLP might not be primarily targeted to oral keratinocytes but to an unknown antigen in the connective tissue stroma. The changes in the subepithelial extracellular matrix associated with the inflammatory reaction might, especially in the atrophic variant, impair the cross-talk between ...Continue Reading

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Citations

Apr 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·N P DekkerJ A Regezi
Mar 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J LiM H Thornhill
Oct 27, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Maria SiponenTuula Salo
Feb 13, 2001·Journal of Cutaneous Pathology·X J ZhouL J Walsh
Mar 6, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C ScullyD Wray
Sep 2, 2020·European Journal of Oral Sciences·Olav SchreursKarl Schenck
Sep 1, 1996·Oral Diseases·L R Eversole
Jan 8, 1998·Seminars in Cutaneous Medicine and Surgery·L R Eversole
Sep 1, 1996·Oral Diseases·V Ramirez-AmadorJ A Regezi
Aug 8, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mariana Villarroel DorregoFelix J Tapia
May 1, 1997·Mund-, Kiefer- und Gesichtschirurgie : MKG·M VesperT Löning

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