Altered expression of pro- and anti-inflammatory cytokines is associated with reduced cardiac function in rats following coronary microembolization.

Molecular and Cellular Biochemistry
Lang LiWeiming Wen

Abstract

Coronary microembolization (CME) is a spontaneous event in patients with ischemic heart disease and a potential iatrogenic complication in patients undergoing coronary interventions. CME induces an obvious inflammatory reaction, characterized by cellular infiltration, particularly of eosinophils, and multifocal microinfarcts. However, little is known on the correlation between pro- and anti-inflammatory cytokines and cardiac function following CME. In this study, microspheres with a diameter of 42 mum were intracoronarily injected into the apex of the left ventricle to induce CME (CME group). Rats injected with normal saline served as controls (sham operated control group). Expression of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and an anti-inflammatory cytokine, IL-10, was measured at 3, 6, 12, 24 h, and 4 weeks post-injection by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry. At the same time points, cardiac function and histological changes were evaluated by echocardiographic imagining and H&E staining, respectively. It was observed that the mRNA and protein expressions of TNF-alpha, IL-1beta, and IL-10 all started to increase at 3 h, reached to the peak levels at 12 h, and return...Continue Reading

References

Mar 11, 1999·The American Journal of Cardiology·P AukrustL Gullestad
Jul 18, 2000·Journal of the American College of Cardiology·R Erbel, G Heusch
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M K LevingsM G Roncarolo
Jan 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Andreas SkyschallyGerd Heusch
Jan 29, 2002·Journal of Molecular and Cellular Cardiology·Hilmar DörgeGerd Heusch
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M GõsslE L Ritman
Jul 10, 2004·Journal of Molecular and Cellular Cardiology·Gerd HeuschRaimund Erbel
May 26, 2005·Journal of Molecular and Cellular Cardiology·Andreas SkyschallyGerd Heusch
Jul 18, 2006·Current Medicinal Chemistry·Nikolaos G Frangogiannis
Aug 15, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shusen YangYihui Kong

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Citations

Jan 18, 2019·Journal of Cellular Biochemistry·Binghui KongQiang Su
Jun 12, 2018·Angiology·Manolis S KallistratosAthanasios J Manolis
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiang SuZhenbai Qin
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiang SuLang Li

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