PMID: 7539536Mar 1, 1995Paper

Altered extracellular matrix component gene expression in murine polycystic kidney

Renal Physiology and Biochemistry
I EbiharaH Koide

Abstract

The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to that seen in the autosomal dominant form of human polycystic kidney disease. This study was designed to assess how the expression of extracellular matrix component genes is regulated in a model of murine polycystic kidney disease and control DBA/2 mice at 8, 16, and 30 weeks of age. The mRNA levels encoding for collagen IV, the B1 and B2 chains of laminin, heparan sulfate proteoglycan, fibronectin, and collagens I and III increased with the progression of cystic lesions in the kidney of DBA/2FG-pcy mice. At 30 weeks of age, mRNA levels for collagen IV, laminin B1 and B2, heparan sulfate proteoglycan, fibronectin, and collagens I and III were increased 8.1-fold, 7.0-fold, 7.0-fold, 9.8-fold, 7.0-fold, 5.5-fold, and 5.4-fold, respectively, compared to those of control DBA/2 mice. An immunofluorescence study revealed the irregular staining for collagen IV, laminin, heparan sulfate proteoglycan, and collagens I and III around the cysts. These data suggest that changes in the expression of basement membrane components and interstitial collagens are associated with the development of polycystic kidney disease.

Citations

Mar 26, 2010·Disease Models & Mechanisms·Steve MangosIain A Drummond
Oct 10, 2002·Kidney International·Vincent H GattoneRobert M Klein
Sep 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Noriyuki Sugiyama, Takahiko Yokoyama
Jan 6, 2005·The American Journal of Pathology·Yasunori SatoYasuni Nakanuma
Mar 15, 2011·Biochimica Et Biophysica Acta·Iain A Drummond
Jul 28, 2016·World Journal of Nephrology·Michelle H T TaGopala K Rangan
May 1, 1997·The British Journal of Surgery·G Morris-StiffR Lord

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