Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves

PloS One
Weijie WuChao Liu

Abstract

In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the anteroposterior axis before the onset of palatal fusion. Fgf10 specifically expressed in lateral mesenchyme of palate maintains Shh transcription in lateral epithelium, while Fgf7 activated in medial mesenchyme by Dlx5, suppressed the expansion of Shh expression to medial epithelium. How FGF signaling pathways regulate the cell behaviors of developing palate remains elusive. In our study, we found that when Fgf8 is ectopically expressed in the embryonic palatal mesenchyme, the elevation of palatal shelves is impaired and the posterior palatal shelves are enlarged, especially in the medial side. The palatal deformity results from the drastic increase of cell proliferation in posterior mesenchyme and decrease of cell proliferation in epithelium. The expression of mesenchymal Fgf10 and epithelial Shh in the lateral palate, as well as the Dlx5 and Fgf7 transcription in the medial mesenchyme are all interrupted, indicating that the epithelial-mesenchymal interactions during palatogenesis are disrupted by the ectopic activation of mesenchymal Fgf8. Besides the altered Fgf7, Fgf10, Dlx5 and Shh expression pattern, the reduced Osr2 expression dom...Continue Reading

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Citations

Mar 15, 2016·Toxicology and Applied Pharmacology·Zhan GaoZengli Yu
Jan 18, 2018·Journal of Dental Research·J XuY P Chen
Dec 9, 2017·Frontiers in Physiology·Dennis O OkelloAdil J Nazarali
Nov 19, 2017·American Journal of Medical Genetics. Part a·Ariadna González-Del AngelPaola Moyers-Pérez
Jul 16, 2020·Birth Defects Research·Kurt ReynoldsChengji J Zhou
Dec 3, 2016·Frontiers in Physiology·Muhammad Abdur RazzakMohammad T Rahman
Jul 22, 2018·Journal of Developmental Biology·Joseph T TarrSteven N Popoff
Dec 26, 2018·Journal of Dental Research·R LiZ Chen
Apr 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengjia WengZhenqi Chen

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