Altered fibrin-clot properties are associated with retinopathy in type 2 diabetes mellitus

Diabetes & Metabolism
M Walus-MiarkaAnetta Undas

Abstract

The development and progression of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) have been associated with poor glycaemic control, long disease duration and other clinical features. However, the pathogenesis of the complication is still poorly understood. As the formation of dense fibrin clots resistant to lysis has been described in diabetes patients, this study tested the hypothesis that altered clot structure and function are associated with DR in T2DM patients. The study included 101 T2DM subjects without DR (NDR) and 60 with DR. Plasma fibrin-clot permeation was assessed using a pressure-driven system, and expressed as the permeation coefficient (K(s)), indicating pore size, and as the time required for a 50% decrease in clot turbidity (t(50%)) as a marker of susceptibility to fibrinolysis. All patients underwent ophthalmological examination. Clinical and biochemical co-variables were also measured. Determinants of DR were identified using stepwise, multivariable, logistic-regression analyses. Patients with DR had lower clot permeability (K(s): 6.15 ± 1.18 vs. 7.53 ± 1.24 10(-9) cm(2); P < 0.0001) and slower fibrin-clot lysis (t(50%): 10.12 ± 1.24 vs. 9.12 ± 1.4 min; P < 0.0001) than NDR subjects. Logistic a...Continue Reading

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Citations

Mar 29, 2014·Thrombosis and Haemostasis·A Undas
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Apr 4, 2017·Journal of Biomedical Materials Research. Part a·David G NortonRodney D Averett
Jun 2, 2017·Thrombosis and Haemostasis·Małgorzata KonieczyńskaAnetta Undas
Oct 8, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jun LiuCheng-Dong Hu

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