Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism

Molecular Imaging
Shiyu TangSu Xu

Abstract

MET, the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD). Genetically altered mice with a kinase-inactive Met offer a potential model for understanding neural circuit organization changes in autism. Here, we focus on the somatosensory thalamocortical circuitry because distinct somatosensory sensitivity phenotypes accompany ASD, and this system plays a major role in sensorimotor and social behaviors in mice. We employed resting-state functional magnetic resonance imaging and in vivo high-resolution proton MR spectroscopy to examine neuronal connectivity and neurotransmission of wild-type, heterozygous Met-Emx1, and fully inactive homozygous Met-Emx1 mice. Met-Emx1 brains showed impaired maturation of large-scale somatosensory network connectivity when compared with wild-type controls. Significant sex × genotype interaction in both network features and glutamate/gamma-aminobutyric acid (GABA) balance was observed. Female Met-Emx1 brains showed significant connectivity and glutamate/GABA balance changes in the somatosensory thalamocortical system when compared with wild-type brains. The glutamate/GABA ratio in the thalamus was correlated with the ...Continue Reading

References

Jun 19, 2001·NMR in Biomedicine·S W Provencher
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chang-Goo HuhSnorri S Thorgeirsson
Apr 15, 2004·Human Brain Mapping·Tianzi JiangXuchu Weng
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel B CampbellPat Levitt
Dec 7, 2006·Developmental Neuroscience·Gabriela J MartinsElizabeth M Powell
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Nov 13, 2008·European Journal of Human Genetics : EJHG·Inês SousaUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
May 5, 2009·PLoS Computational Biology·Damien A FairSteven E Petersen
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Judy-Fay FerronFlorin Amzica
Aug 8, 2009·The European Journal of Neuroscience·Kazuto MasamotoSeong-Gi Kim
Aug 15, 2009·Autism Research : Official Journal of the International Society for Autism Research·Pamela B JacksonCharles E Schwartz
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Dec 25, 2009·Neuroradiology·Judith S VerhoevenStefan Sunaert
Jan 1, 2010·Social Cognitive and Affective Neuroscience·Craig M BennettMichael B Miller
Mar 9, 2010·Trends in Cognitive Sciences·Marcus E Raichle
May 25, 2010·Trends in Cognitive Sciences·Steven L Bressler, Vinod Menon
Jul 10, 2010·Neuroscience Research·Ismail ThanseemNorio Mori
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·P HagmannP E Grant
Jun 1, 2010·Journal of Neurodevelopmental Disorders·Carissa J Cascio
May 10, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Su XuRadi Masri
May 23, 2012·The European Journal of Neuroscience·Reha S Erzurumlu, Patricia Gaspar
Jul 31, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Katharina DworzynskiFrancesca Happé
Aug 16, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Janna L HarrisWilliam M Brooks
Oct 11, 2012·Trends in Cognitive Sciences·Daniel P Kennedy, Ralph Adolphs
Feb 15, 2013·Current Opinion in Neurology·Donna M Werling, Daniel H Geschwind
Mar 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Donna M Werling, Daniel H Geschwind
Jun 29, 2013·Journal of Neurodevelopmental Disorders·Pablo BarttfeldMariano Sigman
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gustavo DecoMaurizio Corbetta
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·Qawi K TelesfordJames B Daunais
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuzheng HuYihong Yang
Feb 25, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Belén Guerra-CarrilloSilvia A Bunge
Jun 28, 2014·Neonatology·Soo Hyun KwonLaura R Ment

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Citations

Apr 20, 2019·Pediatric Research·Panagiotis Kratimenos, Anna A Penn
Nov 18, 2020·Experimental Brain Research·Yusra MansourRandy Kulesza

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Software Mentioned

SPSS Statistics
LCModel
AFNI
FASTMAP
3dClustSim
SPM12
rsfMRI

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