Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice.

Arthritis Research & Therapy
Nicolas Delaleu, Roland Jonsson

Abstract

Sjögren's syndrome is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathological autoimmune reaction. Previous studies in mice indicated that delayed organogenesis and aberrant cell physiology followed by an increase in acinar cell apoptosis precede chronic focal inflammation in the salivary glands and the manifestation of impaired exocrine gland secretion. In a recent study by Wildenberg and colleagues, the authors report aberrant proteolytic activity in the salivary glands of non-obese diabetic mice and the generation of a unique organ-specific 17 kDa fragment of the chemokine and adhesion molecule fractalkine.

References

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Sep 13, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Hisanori UmeharaToshio Imai
Apr 22, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Lisa R LatchneyStephen Dewhurst
Jun 13, 2006·Modern Rheumatology·Hisanori UmeharaToshirou Okazaki
Nov 1, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Smruti J KilledarSeunghee Cha
Jun 21, 2008·Arthritis Research & Therapy·Manon E WildenbergMarjan A Versnel
Nov 6, 2008·Rheumatic Diseases Clinics of North America·Nicolas DelaleuRoland Jonsson

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