Altered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions

NeuroImage. Clinical
Peter GoodinLeeanne M Carey

Abstract

One in two survivors experience impairment in touch sensation after stroke. The nature of this impairment is likely associated with changes associated with the functional somatosensory network of the brain; however few studies have examined this. In particular, the impact of lesioned hemisphere has not been investigated. We examined resting state functional connectivity in 28 stroke survivors, 14 with left hemisphere and 14 with right hemisphere lesion, and 14 healthy controls. Contra-lesional hands showed significantly decreased touch discrimination. Whole brain functional connectivity (FC) data was extracted from four seed regions, i.e. primary (S1) and secondary (S2) somatosensory cortices in both hemispheres. Whole brain FC maps and Laterality Indices (LI) were calculated for subgroups. Inter-hemispheric FC was greater in healthy controls compared to the combined stroke cohort from the left S1 seed and bilateral S2 seeds. The left lesion subgroup showed decreased FC, relative to controls, from left ipsi-lesional S1 to contra-lesional S1 and to distributed temporal, occipital and parietal regions. In comparison, the right lesion group showed decreased connectivity from contra-lesional left S1 and bilateral S2 to ipsi-lesiona...Continue Reading

Citations

Feb 17, 2021·Journal of Neuroengineering and Rehabilitation·Sa ZhouXiaoling Hu
Apr 8, 2021·Neurorehabilitation and Neural Repair·Sarah N KraeutnerLara A Boyd
May 24, 2021·NeuroImage. Clinical·Simon S KessnerBastian Cheng
Jun 18, 2021·Stroke; a Journal of Cerebral Circulation·Chia-Lin KohLeeanne M Carey

❮ Previous
Next ❯

Software Mentioned

nibabel
multcomp
Scipy
SPM
iBrain Tools for SPM
SPM8
NiPype
SPM12
lme4
R

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.