Altered functional connectivity of the amygdaloid input nuclei in adolescents and young adults with autism spectrum disorder: a resting state fMRI study

Molecular Autism
Annika RauschWouter B Groen

Abstract

Amygdala dysfunction is hypothesized to underlie the social deficits observed in autism spectrum disorders (ASD). However, the neurobiological basis of this hypothesis is underspecified because it is unknown whether ASD relates to abnormalities of the amygdaloid input or output nuclei. Here, we investigated the functional connectivity of the amygdaloid social-perceptual input nuclei and emotion-regulation output nuclei in ASD versus controls. We collected resting state functional magnetic resonance imaging (fMRI) data, tailored to provide optimal sensitivity in the amygdala as well as the neocortex, in 20 adolescents and young adults with ASD and 25 matched controls. We performed a regular correlation analysis between the entire amygdala (EA) and the whole brain and used a partial correlation analysis to investigate whole-brain functional connectivity uniquely related to each of the amygdaloid subregions. Between-group comparison of regular EA correlations showed significantly reduced connectivity in visuospatial and superior parietal areas in ASD compared to controls. Partial correlation analysis revealed that this effect was driven by the left superficial and right laterobasal input subregions, but not the centromedial output...Continue Reading

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Citations

Jan 30, 2016·Human Brain Mapping·Marie-Andree CoulombeKaren Deborah Davis
Mar 5, 2020·Autism Research : Official Journal of the International Society for Autism Research·Aubrey N SciaraMichelle J Chandley
Aug 21, 2019·Frontiers in Neuroscience·Shoujun XuGuihua Jiang
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Dec 7, 2019·Computer Methods and Programs in Biomedicine·Liangliang ZhangLihua Li
Oct 10, 2021·Journal of Magnetic Resonance Imaging : JMRI·Faranak RafieeIlyssa J Yousem

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Software Mentioned

MCFLIRT
FSL FMRIB
Randomise
Brain Extraction Tool ( BET )
PRELUDE
FUGUE
FSL
SPSS

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