Altered Functional Connectivity of the Basal Nucleus of Meynert in Mild Cognitive Impairment: A Resting-State fMRI Study

Frontiers in Aging Neuroscience
Hui LiKuncheng Li

Abstract

Background: Cholinergic dysfunction plays an important role in mild cognitive impairment (MCI). The basal nucleus of Meynert (BNM) provides the main source of cortical cholinergic innervation. Previous studies have characterized structural changes of the cholinergic basal forebrain in individuals at risk of developing Alzheimer's disease (AD). However, whether and how functional connectivity of the BNM (BNM-FC) is altered in MCI remains unknown. Objective: The aim of this study was to identify alterations in BNM-FC in individuals with MCI as compared to healthy controls (HCs), and to examine the relationship between these alterations with neuropsychological measures in individuals with MCI. Method: One-hundred-and-one MCI patients and 103 HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI). Imaging data were processed with SPM8 and CONN software. BNM-FC was examined via correlation in low frequency fMRI signal fluctuations between the BNM and all other brain voxels. Group differences were examined with a covariance analysis with age, gender, education level, mean framewise displacement (FD) and global correlation (GCOR) as nuisance covariates. Pearson's correlation was conducted to evaluate the relations...Continue Reading

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Citations

Sep 12, 2018·Radiology·Dewen MengUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 6, 2020·Annals of Clinical and Translational Neurology·Weimin ZhengZhiqun Wang
Jun 16, 2018·Frontiers in Physiology·Lingguo BuJianfeng Li
Feb 14, 2020·Current Alzheimer Research·Zhongke GaoUNKNOWN Alzheimer’s DiseaseNeuroimaging Initiative
Jul 12, 2020·Medicina·Delia TulbăEugenia Irene Davidescu
Jul 4, 2021·NeuroImage. Clinical·Elizabeth P PasmanMark G Carpenter

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Software Mentioned

CompCor
SPM8 ( CONN )
SPSS
3dClustSim
AFNI

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