Altered functional network connectivity relates to motor development in children born very preterm

NeuroImage
M D WheelockC D Smyser

Abstract

Individuals born very preterm (<32 weeks gestation) are at increased risk for neuromotor impairments. The ability to characterize the structural and functional mechanisms underlying these impairments remains limited using existing neuroimaging techniques. Resting state-functional magnetic resonance imaging (rs-fMRI) holds promise for defining the functional network architecture of the developing brain in relation to typical and aberrant neurodevelopment. In 58 very preterm and 65 term-born children studied from birth to age 12 years, we examined relations between functional connectivity measures from low-motion rs-fMRI data and motor skills assessed using the Movement Assessment Battery for Children, 2nd edition. Across all subscales, motor performance was better in term than very preterm children. Examination of relations between functional connectivity and motor measures using enrichment analysis revealed between-group differences within cerebellar, frontoparietal, and default mode networks, and between basal ganglia-motor, thalamus-motor, basal ganglia-auditory, and dorsal attention-default mode networks. Specifically, very preterm children exhibited weaker associations between motor scores and thalamus-motor and basal gangl...Continue Reading

Citations

Aug 12, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Megan E NorrMoriah E Thomason
Dec 14, 2018·Journal of Neurodevelopmental Disorders·Cynthia E RogersChristopher D Smyser
Apr 3, 2021·Frontiers in Bioengineering and Biotechnology·Marine Jequier GygaxJulien Favre
Jun 1, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Megan Ní BhroinArun L W Bokde
Jul 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Moriah E ThomasonPaul Curtin
Jun 27, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Kirsten E GilbertDeanna M Barch
Aug 3, 2021·Pediatric Neurology·Karoliina UusitaloUNKNOWN PIPARI Study Group
Jan 29, 2020·NeuroImage·Andrew K FishellJoseph P Culver

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