Altered functional status of the hypothalamic dopaminergic tone in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a pilot study

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Adalberto ParraGuillermo J Ruiz-Argüelles

Abstract

We compared the functional status of the hypothalamic dopaminergic tone in patients given an allogeneic hematopoietic stem cell transplantation (allo-HSCT) with chronic graft-versus-host disease (GVHD) with that observed in patients with allo-HSCT without chronic GVHD and in healthy controls. The effect of acute dopaminergic blockade with intravenous metoclopramide on serum prolactin (PRL) concentrations was evaluated. Twenty volunteers, 20 to 52 years of age, seronegative for both hepatitis C virus and the human immunodeficiency virus, were studied: (1) 10 clinically healthy men (group 1), and (2) 9 patients with leukemia, and 1 patient with refractory aplastic anemia who underwent allo-HSCT, 5 of whom (3 men and 2 women) developed chronic GVHD (group 2), and 5 (3 men and 2 women) who did not develop chronic GVHD (group 3). Serum PRL concentrations were measured both fasting and after intravenous administration of metoclopramide (10-mg bolus). The area under the PRL curve was calculated. Patients in group 2 were older than those in groups 1 and 3 (P<.018), but their body mass index was similar. Fasting serum PRL concentrations were similar among the 3 groups; however, group 2 had higher PRL concentrations throughout the test (...Continue Reading

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Citations

Jan 19, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amit AkirovShereen Ezzat
May 12, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Anke Heidewig HautmannErnst Holler
Jul 26, 2016·Experimental and Therapeutic Medicine·Nataša Karas-KuželičkiIrena Mlinarič-Raščan
Oct 14, 2020·European Journal of Haematology·Maria Queralt SalasJeffrey Howard Lipton

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