PMID: 16639388Apr 28, 2006Paper

Altered glucose metabolism in obese youth

Pediatric Endocrinology Reviews : PER
Ram Weiss, Sonia Caprio

Abstract

Altered glucose metabolism in obese youth is associated with defects in insulin sensitivity and insulin secretion. Peripheral insulin resistance in obese youth is an early phenomenon, strongly associated with a pattern of lipid partitioning characterized by increased deposition of lipid in the visceral and intramyocellular compartments. This metabolic phenotype is further characterized by a relatively reduced adiponectin level and elevation of inflammatory cytokines. A reduced sensitivity of the beta cell for first phase insulin secretion results in impaired glucose tolerance, while reduced first and second phase beta cell sensitivity for insulin secretion results in overt type 2 diabetes. Altered glucose metabolism in obese youth represents an element of the "insulin resistance syndrome", comprising obesity, dyslipidemia and hypertension. The dynamics of glucose tolerance status in these youngsters seems to be more rapid than in adults, thus representing a narrow window of opportunity for successful intervention to prevent diabetes.

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Best Practice & Research. Clinical Endocrinology & Metabolism
Ram Weiss, Sonia Caprio
Przegla̧d lekarski
Joanna Nazim, Jerzy Starzyk
Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
D Yeste, A Carrascosa
© 2022 Meta ULC. All rights reserved