Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus.

Gut Microbes
Xing WangHongbo Qi

Abstract

Emerging evidence indicates that the gut microbiome can modulate metabolic homeostasis, and thus may influence the development of gestational diabetes mellitus (GDM). However, whether and how the gut microbiome and its correlated metabolites change in GDM is uncertain. Herein we compare the gut microbial compositions, and fecal and urine metabolomes, of 59 patients with GDM versus 48 pregnant healthy controls (HCs). We showed that the microbial and metabolic signatures of GDM patients were significantly different from those of HCs. Compared to HCs, the GDM subjects were characterized by enriched bacterial operational taxonomic units (OTUs) of the family Lachnospiraceae, and depleted OTUs of the families Enterobacteriaceae and Ruminococcaceae. Some altered gut microbes were significantly correlated with glucose values and fetal ultrasonography indexes. Moreover, we identified four fecal and 15 urine metabolites that discriminate GDM from HC. These differential metabolites are mainly involved in carbohydrate and amino acid metabolism. Significantly, co-occurrence network analysis revealed that Lachnospiraceae and Enterobacteriaceae bacterial OTUs formed strong co-occurring relationships with metabolites involved in carbohydrate a...Continue Reading

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Citations

May 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Ping HuAn Pan
Oct 3, 2021·Diabetes Research and Clinical Practice·Patricia Medici DualibBianca de Almeida Pititto

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Methods Mentioned

BETA
cesarean section
PCA
PCR

Software Mentioned

scikit
learn
QIIME
SIMCA
PERMANOVA
UCHIME
- P +
Cytoscape
SPSS
ChromaTOF

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