Altered gut microbiome promotes proteinuria in mice induced by Adriamycin

AMB Express
Qian JiangHuimei Chen

Abstract

Inflammation has recently been attributed to dysbiosis of the gut microbiome, which has been linked to proteinuria in chronic kidney disease. Since Adriamycin®(ADR) is widely used to induce proteinuria in mouse models, the aim of this study was to explore the potential effect of gut microbiome on this process. Both ADR resistant (C57BL/6) and susceptible (BALB/C) strains were part of the induced nephropathy with ADR injection. BALB/C mice significantly presented increased urinary albumin/creatinine ratio (UACR) with renal lesions in pathology, but C57BL/6 mice were absent from kidney damage. Species and genus level resolution analysis showed a shift in gut microbial profile between BALB/C and C57BL/6 mice. ADR further altered the stool microbiome in BALB/C mice, particularly with enrichment of Odoribacter and depletion of Turicibacter, Marvinbryantia and Rikenella. Moreover, the level of UACR in BALB/C mice was marked related to the abundance of Marvinbryantia, Odoribacter and Turicibacter in stool. Meanwhile, ADR remarkably increased the serum levels of interleukin (IL)-2 in BALB/C mice, but not in C57BL/6 mice. It is suggested that the favorably altered stools as shown in the microbiome might promote the inflammation and prot...Continue Reading

References

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Citations

Aug 31, 2018·Frontiers in Microbiology·Guanhao WangJing Pan
Nov 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hua MiaoYing-Yong Zhao

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Datasets Mentioned

BETA
PRJNA327732

Methods Mentioned

BETA
Protein Assay
ELISA

Software Mentioned

R Language
PAST
Aligner
Ribosomal Database Project ( RDP ) Classifier
SPSS

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