Abstract
Despite anorexia nervosa having the highest mortality rate of mental illnesses, little is known regarding the brain mechanisms involved. Given that lack of interest for food in anorexic patients is related to alterations in the reward system, we tested the hypothesis that patients with past anorexia nervosa (pAN) have altered resting state functional connectivity (RSFC) between the habenula (a major component of the reward system) and its targets. RSFC between the habenula and major targets (locus coeruleus, median and dorsal raphe nuclei, substantia nigra, and ventral tegmental area) was studied in 14 psychiatric inpatients with pAN and 14 psychiatric inpatient controls (PC, never-anorexic patients in same clinic, matched for comorbidities). Next, we tested possible correlations between RSFC and suicidal ideation, depression, and anxiety as determined by self-report questionnaires. Left habenula/locus coeruleus RSFC was lower in pAN patients compared to PC. The left habenula/locus coeruleus RSFC was positively correlated with suicidal ideation (past 2 months) in pAN patients, but not in controls. pAN patients showed long lasting alterations in habenular connectivity. This may have clinical implications, possibly including futu...Continue Reading
References
Mar 11, 2006·The International Journal of Eating Disorders·Angela WagnerWalter H Kaye
Jul 6, 2011·Archives of General Psychiatry·Jon ArcelusSøren Nielsen
Oct 18, 2011·Psychological Medicine·A Y DombrovskiH Aizenstein
Oct 4, 2012·Human Brain Mapping·Felicity A CowdreyCiara McCabe
May 16, 2013·PloS One·Yasuhiro SatoShin Fukudo
Dec 5, 2013·Psychiatry Research·Seojung LeeYoung-Chul Jung
Oct 18, 2014·Frontiers in Behavioral Neuroscience·Ilka BoehmStefan Ehrlich
Sep 30, 2015·Psychiatry Research·Sara UlfvebrandYvonne von Hausswolff-Juhlin
Mar 19, 2016·Human Brain Mapping·Benjamin A ElyEmily R Stern
Dec 20, 2016·The European Journal of Neuroscience·Antonietta CannaFabrizio Esposito
Feb 25, 2017·The American Journal of Psychiatry·Marisa DeGuzmanGuido K W Frank
Apr 4, 2017·Acta Psychiatrica Scandinavica·E AmbrosiR Salas
Sep 1, 2017·The American Journal on Addictions·Kaylah CurtisRamiro Salas
Oct 14, 2017·Biological Psychiatry·Fabio BernardoniStefan Ehrlich
Mar 27, 2018·Journal of Cachexia, Sarcopenia and Muscle·Maria MaldonadoRamiro Salas
Sep 1, 2018·Brain Stimulation·Anton FomenkoAndres M Lozano
Oct 5, 2018·The Journal of Neuropsychiatry and Clinical Neurosciences·Elisa AmbrosiRamiro Salas
Oct 6, 2018·Eating and Weight Disorders : EWD·Margarita SalaAndrea B Goldschmidt
Nov 23, 2018·Neuropsychiatric Disease and Treatment·Ignacio Jáuregui-Lobera, José V Martínez-Quiñones
May 10, 2019·F1000Research·Guido K W FrankMarisa C DeGuzman