Altered hemispheric asymmetry of auditory P100m in dyslexia

The European Journal of Neuroscience
Sabine HeimT Elbert

Abstract

In various studies, deviances of hemispheric laterality in the organization of the perisylvian region in dyslexia have been suggested. Although associated with impaired language functioning, the clinical significance of atypical cerebral lateralization remains unclear. The present study examined interhemispheric source differences of magnetic responses to the German synthetic syllable [ba:] in the auditory cortex of 14 dyslexic children and 12 normally literate controls aged 8-15 years. In all subjects, two main deflections, P100m and N260m, were evident in the responses over each hemisphere. While in the control group the right P100m dipole was located more anterior than the corresponding dipole of the left hemisphere, the dyslexic group displayed a rather symmetrical source configuration between the hemispheres. This symmetry reflected a deviance in the right perisylvian region for the dyslexic subjects' P100m, which was generated approximately 1 cm more posterior than the response in controls. The deviation was also obvious relative to the source location of the later component, N260m, which did not systematically differ between the participant groups. Our results suggest that the altered hemispheric asymmetry reflects an at...Continue Reading

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Citations

Jun 13, 2006·Experimental Brain Research·Sabine Heim, Andreas Keil
Oct 2, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Huizhen TangBlake W Johnson
May 14, 2011·Neuroscience Letters·Azizuddin KhanHeikki Lyytinen
Dec 4, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Blake W JohnsonMelanie Reid
Feb 9, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Odelia ElkanaAvraham Schweiger
Sep 20, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Catherine Sebastian, Ifat Yasin
Apr 9, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Minna HuotilainenJyri Hukki
Apr 5, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Michael C Corballis
Feb 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N A TaroyanA J Fawcett
Aug 4, 2010·Dyslexia : the Journal of the British Dyslexia Association·Stefan HeimKatrin Amunts
Sep 1, 2005·Neuropsychologia·Isabella PaulThomas Elbert
Oct 18, 2011·NeuroImage·Jarmo A HämäläinenUsha Goswami
Sep 30, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Riitta Salmelin
Nov 26, 2010·Trends in Cognitive Sciences·Usha Goswami
Apr 9, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Thomas Elbert, Brigitte Rockstroh

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