Altered hepatic metabolism of fatty acids in rats fed a hypolipidaemic drug, fenofibrate

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
K YamamotoT Sakai

Abstract

The aim of this study was to examine the effects of dietary fenofibrate (0.05% in the diet) on ketone body production and lipid secretion in isolated perfused rat liver. Feeding with fenofibrate for 7-9 days caused an increased liver weight. Ketone body production was significantly greater in the livers perfused with oleic acid than in those perfused without fatty acid, with the elevation of the ratio of beta-hydroxybutyrate:acetoacetate indicating an increased redox potential in mitochondrial compartments by exogenous fatty acid. On the other hand, fenofibrate feeding caused a further stimulation of ketone body production from both endogenous and exogenous fatty acid substrates, respectively, with a decreased ratio of beta-hydroxybutyrate:acetoacetate as compared to respective control livers, indicating a decreased redox potential. Hepatic secretion of triglyceride, but not of cholesterol, was decreased markedly in the fenofibrate-fed rats, especially when oleate was provided, suggesting an inverse relationship between rates of ketogenesis and triglyceride secretion. These results suggest that the altered hepatic metabolism of long-chain fatty acids between oxidation and esterification caused by fenofibrate may thus be a facto...Continue Reading

Citations

Jun 29, 2006·Journal of Nutritional Science and Vitaminology·Shizuka TamaruKunio Suzuki
Feb 13, 2016·Frontiers in Endocrinology·Maja M GrabackaKrzysztof Reiss
Oct 26, 1999·The Annals of Pharmacotherapy·D R Guay
Jul 18, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mi-Kyoung ParkHye-Jeong Lee
Apr 21, 2016·PloS One·Karen R JonscherMichael J Pecaut
Apr 21, 2010·The Journal of Pharmacology and Experimental Therapeutics·Jennifer Tremblay-MercierStephen C Cunnane
May 29, 2014·American Journal of Physiology. Endocrinology and Metabolism·David G CotterPeter A Crawford

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