Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.

Science
Joshua J Bayes, Harmit S Malik

Abstract

Hybrid sterility of the heterogametic sex is one of the first postzygotic reproductive barriers to evolve during speciation, yet the molecular basis of hybrid sterility is poorly understood. We show that the hybrid male sterility gene Odysseus-site homeobox (OdsH) encodes a protein that localizes to evolutionarily dynamic loci within heterochromatin and leads to their decondensation. In Drosophila mauritiana x Drosophila simulans male hybrids, OdsH from D. mauritiana (OdsHmau) acts as a sterilizing factor by associating with the heterochromatic Y chromosome of D. simulans, whereas D. simulans OdsH (OdsHsim) does not. Characterization of sterile hybrid testes revealed that OdsH abundance and localization in the premeiotic phases of spermatogenesis differ between species. These results reveal that rapid heterochromatin evolution affects the onset of hybrid sterility.

References

Apr 1, 1995·American Annals of the Deaf
Oct 1, 1996·Trends in Genetics : TIG·J Forejt
Dec 29, 1998·Science·M Nei, J Zhang
May 17, 2002·Nature·Steven Henikoff, Harmit S Malik
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chau-Ti TingChung-I Wu
Sep 9, 2006·Science·John P MaslyH Allen Orr
Nov 25, 2006·Science·Nicholas J BrideauDaniel A Barbash
Sep 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefanie D Hueber, Ingrid Lohmann
Dec 17, 2008·Science·Ondrej MiholaJiri Forejt
Sep 22, 2009·Cell·Harmit S Malik, Steven Henikoff

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Citations

Nov 5, 2011·Journal of Molecular Evolution·Daina Ma, Pawel Michalak
Aug 10, 2010·Genetica·Jorge Ernesto Quezada-DíazEsther Betrán
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Timothy B SacktonBernardo Lemos
Sep 10, 2011·Genome Biology and Evolution·Masatoshi Nei, Masafumi Nozawa
Dec 22, 2010·Molecular Biology and Evolution·Kelly A DyerAndrea J Betancourt
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Shannon R McDermott, Mohamed A F Noor
May 11, 2010·Cold Spring Harbor Symposia on Quantitative Biology·C D Malone, G J Hannon
Dec 23, 2011·International Journal of Evolutionary Biology·Kyoichi Sawamura
Mar 4, 2011·BMC Evolutionary Biology·Nicholas J Brideau, Daniel A Barbash
Nov 29, 2012·PLoS Biology·Erin S KelleherDaniel A Barbash
Dec 10, 2009·PLoS Genetics·Peter L OliverChris P Ponting
Mar 4, 2014·PLoS Genetics·Leslie M TurnerBret A Payseur
May 5, 2012·Genetics·Michael A WhiteBret A Payseur
Nov 3, 2012·International Journal of Evolutionary Biology·Rama Singh, Santosh Jagadeeshan
Jun 23, 2011·Pharmacogenomics·Hye-Young NamJae-Pil Jeon
Jan 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tanmoy BhattacharyyaJiri Forejt
Mar 13, 2014·Molecular Biology and Evolution·Devjanee Swain LenzJustin C Fay
May 23, 2014·Genome Biology and Evolution·Miguel Gallach
May 20, 2014·Integrative and Comparative Biology·I MendizabalSoojin V Yi
May 9, 2012·Genetics Research International·Patrick M Ferree, Satyaki Prasad
Jul 10, 2014·Genome Génome / Conseil National De Recherches Canada·Sachin ThapaShailika Chhetri
May 5, 2010·Annual Review of Genomics and Human Genetics·Judith D Brown, Rachel J O'Neill
Sep 14, 2011·Annual Review of Genetics·Shamoni Maheshwari, Daniel A Barbash
Dec 17, 2010·Genetic Testing and Molecular Biomarkers·Khangembam Somibabu MeiteiKallur Nava Saraswathy
Apr 14, 2011·Genetic Testing and Molecular Biomarkers·Prakash Ranjan MondalKallur Nava Saraswathy
Jan 7, 2010·Nature Reviews. Genetics·Daven C Presgraves
Apr 17, 2010·Nature Reviews. Genetics·Noah A RosenbergMichael Boehnke
Feb 19, 2011·Nature Reviews. Genetics·Manfred Kayser, Peter de Knijff

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