Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.

Synapse
L LyonP W J Burnet

Abstract

Group II metabotropic glutamate receptors (mGluR2 and mGluR3, also called mGlu2 and mGlu3, encoded by GRM2 and GRM3, respectively) are therapeutic targets for several psychiatric disorders. GRM3 may also be a schizophrenia susceptibility gene. mGluR2-/- and mGluR3-/- mice provide the only unequivocal means to differentiate between these receptors, yet interpretation of in vivo findings may be complicated by secondary effects on expression of other genes. To address this issue, we examined the expression of NMDA receptor subunits (NR1, NR2A, NR2B) and glutamate transporters (EAAT1-3), as well as the remaining group II mGluR, in the hippocampus of mGluR2-/- and mGluR3-/- mice, compared with wild-type controls. mGluR2 mRNA was increased in mGluR3-/- mice, and vice versa. NR2A mRNA was increased in both knockout mice. EAAT1 (GLAST) mRNA and protein, and EAAT2 (GLT-1) protein, were reduced in mGluR3-/- mice, whereas EAAT3 (EAAC1) mRNA was decreased in mGluR2-/- mice. Transcripts for NR1 and NR2B were unchanged. The findings show a compensatory upregulation of the remaining group II metabotropic glutamate receptor in the knockout mice. Upregulation of NR2A expression suggests modified NMDA receptor signaling in mGluR2-/- and mGluR3-/...Continue Reading

References

Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Jul 1, 1997·Molecular Pharmacology·G Gegelashvili, A Schousboe
Feb 12, 1999·Brain Research. Brain Research Reviews·R Anwyl
Jun 22, 2000·Nature Neuroscience·M Sheng, S H Lee
Aug 11, 2000·Journal of Neurochemistry·J Cartmell, D D Schoepp
Jun 12, 2001·Current Opinion in Neurobiology·S Cull-CandyM Farrant
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Dec 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marc FlajoletPaul Greengard
Jun 19, 2004·Psychopharmacology·J David Sweatt
Jun 24, 2004·Brain Research. Brain Research Reviews·Yasushi ShigeriKeiko Shimamoto
Jul 21, 2004·Molecular Psychiatry·P J Harrison, D R Weinberger
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael F EganDaniel R Weinberger
Jan 25, 2005·Nature Reviews. Drug Discovery·Chad J SwansonDarryle D Schoepp
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yosuke MorishimaShigetada Nakanishi
Jan 19, 2006·Journal of Neurochemistry·Leah J SartoriusPaul J Harrison
Oct 20, 2006·Journal of Psychopharmacology·Sharon L EastwoodPaul J Harrison
Dec 2, 2006·The Journal of Biological Chemistry·Guilian TianChien-Liang Glenn Lin
Jan 27, 2007·Cellular and Molecular Life Sciences : CMLS·S J Martin, R E Clark
May 29, 2007·Biological Psychiatry·Corrado CortiFrancesco Ferraguti
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hao-Yang TanJoseph H Callicott
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Corrado CortiValeria Bruno
Aug 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduardo DunayevichGary D Tollefson
Feb 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Paul J Harrison
Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leah J SartoriusBarbara K Lipska

❮ Previous
Next ❯

Citations

Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathleen M GrantRick A Bevins
Aug 13, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Louisa LyonDavid M Bannerman
Aug 14, 2013·PloS One·Vendula RusnakovaMiroslava Anderova
Oct 29, 2013·Cellular and Molecular Life Sciences : CMLS·Massimiliano G BianchiOvidio Bussolati
Dec 24, 2013·Pharmacology & Therapeutics·Lucyna Pomierny-ChamiołoMałgorzata Filip
Jul 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Unn Kristin HaukvikIngrid Agartz
Jan 12, 2010·Neuroscience and Biobehavioral Reviews·Suat Ying Tan CherlynKang Sim
Aug 19, 2009·Journal of Neurochemistry·Pablo A GasparFrancisco Aboitiz
Mar 2, 2011·Synapse·Louisa LyonAntonio Rodríguez-Moreno
Sep 12, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Harpreet KaurRitushree Kukreti
May 9, 2012·Neuropharmacology·Daniela DurandMercedes Lasaga
Mar 6, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Changjiu Zhao, Stephen C Gammie
Mar 25, 2014·The Journal of Pharmacology and Experimental Therapeutics·John O DiRaddoJarda T Wroblewski
Nov 16, 2019·International Journal of Molecular Sciences·Anna R Malik, Thomas E Willnow
May 16, 2021·Neuropharmacology·Ada G Rodríguez-Campuzano, Arturo Ortega
Aug 14, 2021·Scandinavian Journal of Pain·Maria Carla GerraMaria Teresa Carrillo-de-la-Peña

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
pharmacotherapy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.