Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements

Journal of Neuroendocrinology
Frank C van BusselJacobus F Jansen

Abstract

Type 2 diabetes mellitus is associated with cognitive decrements. Specifically affected cognitive domains are learning and memory, for which the hippocampus plays an essential role. The pathophysiological mechanism remains to be revealed. The present study examined whether local hippocampal microstructure and white matter connectivity are related to type 2 diabetes and memory performance. Forty participants with type 2 diabetes and 38 participants without type 2 diabetes underwent detailed cognitive assessment and 3-Tesla diffusion magnetic resonance imaging (MRI). Diffusion MRI was performed to assess microstructure (fractional anisotropy and mean diffusivity) and white matter connectivity (tract volume) of the hippocampus, which were compared between participants with and without type 2 diabetes. No differences in hippocampal microstructure were observed. Participants with type 2 diabetes had fewer white matter connections between the hippocampus and frontal lobe (P = 0.017). Participants who scored lower on memory function, regardless of type 2 diabetes, had fewer white matter connections between the hippocampus and temporal lobe (P = 0.017). Taken together, type 2 diabetes and memory decrements appear to be associated with ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 27, 2001·Brain : a Journal of Neurology·S H ErikssonJ S Duncan
Nov 5, 2003·Diabetologia·T den HeijerM M B Breteler
Dec 14, 2004·Journal of Clinical and Experimental Neuropsychology·Nesrine AwadClaude Messier
May 17, 2005·Journal of the International Neuropsychological Society : JINS·Wim Van der ElstJelle Jolles
Jan 31, 2006·Diabetes Care·Christopher M RyanMark W J Strachan
Apr 4, 2008·European Journal of Pharmacology·José Alejandro Luchsinger
Apr 9, 2008·European Journal of Pharmacology·Raoul P KloppenborgGeert Jan Biessels
Oct 14, 2008·Biochimica Et Biophysica Acta·Esther van den BergGeert Jan Biessels
Apr 7, 2009·NeuroImage·Renske de BoerWiro J Niessen
Nov 3, 2009·Diabetologia·E van den BergUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Mar 11, 2011·Human Brain Mapping·Anouk G W van NordenFrank-Erik de Leeuw
Aug 13, 2011·Diabetes Research and Clinical Practice·Kumi HayashiToshitsugu Sugimoto
Nov 1, 2011·Cerebral Cortex·Maarten J VaessenWalter H Backes
Apr 10, 2012·PloS One·René M H BesselingWalter H Backes
Jun 12, 2012·Lancet·Rory J McCrimmonBrian M Frier
Sep 11, 2012·Diabetes Care·Yael D ReijmerUNKNOWN Utrecht Vascular Cognitive Impairment Study Group
Jan 1, 2013·Diabetes Care·Peggy J J SpauwenMartin P J van Boxtel
Jan 26, 2013·Diabetes·Yael D ReijmerUNKNOWN Utrecht Vascular Cognitive Impairment Study Group
Jan 15, 2014·Journal of Clinical and Experimental Neuropsychology·Po Lai YauAntonio Convit
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Natalia García-CasaresPedro González-Santos
Feb 19, 2015·Diabetes Care·Frank C van BusselJacobus F Jansen

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Citations

May 26, 2018·AIDS·Minjie WuUNKNOWN Neuropsychology Working Group of the Multicenter AIDS Cohort Study
Sep 20, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·B MankovskyJ de Bresser
Apr 21, 2017·Frontiers in Neuroscience·Frank C G van BusselJacobus F A Jansen
May 21, 2017·Journal of Alzheimer's Disease : JAD·Chris MoranVelandai Srikanth
May 23, 2020·Neuroscience and Biobehavioral Reviews·Laura W M VergoossenMiranda T Schram
Dec 8, 2020·Frontiers in Public Health·Jing SunGuangxian Nan
Mar 5, 2018·Physiology & Behavior·A C ReicheltK A Page

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