journal cover

Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis

Brain, Behavior, and Immunity

Dec 4, 2012

Gordon BroderickNancy Klimas

Abstract

Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating illness presenting with a complex constellation of immune, endocrine and neurological symptoms. Here we compared male GWI (n=20) with healt...read more

Mentioned in this Paper

Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Lymphocytosis
ZBTB16 gene
Immune Response
Active brand of pseudoephedrine-triprolidine
Flow Cytometry
Neurotrophic Tyrosine Kinase Receptor Type 2
Biochemical Pathway
Microarray Analysis
4
5
60
Paper Details
References
  • References88
  • Citations19
12345...
  • References88
  • Citations19
12

Similar Papers Found In These Feeds

Nervous System in C. elegans

Here is the latest research on structures and gene circuits in the nervous system of model organism C. Elegans.

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Neuronal Tyrosine Kinase Receptors

The binding of neurotropic factors activates tyrosine kinase receptors in both central and peripheral neurons. This signals the correct location, morphology, and integration of neurons into the vast neural network. Discover the latest research of neuronal tyrosine kinase receptors here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

NK Cells: Viral Immunity

Natural Killer (NK) cells are critical for the containment of viral replication, particularly during early infection. Some viruses such as HIV and influenza have developed mechanisms to evade NK detection and infect the host. Here is the latest research on NK cells and viral immunity.

Signal Transduction & Control of Gene Expression

Expression of genes are thought to be involved in signaling pathways, which are important for cell growth, metabolism, apoptosis and more. It is thought that gene expression plays a part in the signaling pathways that implicates the biological effects of the cell. Here is the latest research on signal transduction and the control of gene expression.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Transcriptional Condensates (Keystone)

Enhancers are DNA elements that are bound by transcription factors (TFs). These DNA sequences can drive condensation of TFs and coactivators. Here is the latest research on transcriptional condensates.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Neuromuscular Disorders

Neuromuscular disorders result in impaired functioning of the muscles. Discover the latest research on these disorders, including ALS, and the underlying genetic aspects here.

Genetics of Autoimmunity

Genome-wide association studies have revealed pathways linked to autoimmune disorders and their pathogenesis. Discover the latest research on the Genetics of Autoimmunity here.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Neuronal Remodeling

Neuronal remodeling is a critical step in the development of the mature nervous system and important in the refinement to respond to developmental and environmental influences. Disruption of this process can lead to neuropsychiatric diseases. Here is the latest research on neuronal remodeling.

Parkinson's Disease

Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

NK cell Signaling

Natural killer (NK) cells are cytotoxic cells of the innate immune system that respond to foreign or host cells displaying stress signals. NK cell activity is controlled by engagement of various cell surface receptors that induce activation or inhibitory pathways, the balance of which determines the cell’s phenotype. Find the latest research on NK cell signaling here.

Systemic Lupus Erythematosus

Systemic lupus erythematosus is an autoimmune disorder which can affect and damage any organ system in the body. It has a diverse range of immunological manifestations and is more prominent in young women, with the exact etiology still unknown. Here is the latest research on systemic lupus erythematosus.

Synaptic Transmission in Neurodegeneration

Synaptic alterations are emerging as critical determinants of neurodegeneration. Here is the latest research on alterations of synaptic transmission and plasticity in neurodegeneration and neurodegerative disorders.

MS: Therapies

The feed focuses on therapeutic interventions used to treat Multiple Sclerosis.

Hypothalamic Neoplasms

Hypothalamic tumors are located within the hypothalamus of the brain. The tumors may arise from abnormal growth of glial cells, known as gliomas or may be caused from the spread from surrounding structures, such as optic tumors. Here is the latest research on hypothalamic neoplasms.

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

Motor Neuron Disease

Motor neuron diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy are progressive neurodegenerative diseases that result in the death of motor neurons. Discover the latest research on motor neuron disease here.

Formation of Synapses and Circuits

Synapses are crucial for the transmission of information within neural circuits. These specialized intercellular junctions are the basis for the formation of complex networks. Formation of these synapses involve numerous steps that are essential for transmission of information. Here is the latest research on formation of synapses and circuits.

Neurotransmitters

Neurotransmitters are released from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind specific receptors in order to bring about changes in postsynaptic neurons. Here is the latest research.

Killing Mechanisms

Cytolytic t lymphocytes exert two main specific molecular killing mechanisms against target cells, namely (i) they can synthesize and release soluble cytolytic factors, and (ii) they can express effector molecules that act as ligands of receptors expressed by target cells on the cell surface. Here is the latest research on killing mechanisms.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Killer Cells

Natural killer cells express inhibitory receptors specific for mhc class i proteins and stimulatory receptors with diverse specificities. Here is the latest research on natural killer cells.

T Cell Reactivity to Tau & Alpha-Synuclein in PD

Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the reaction of T lymphocytes in response to tau and alpha-synuclein.

Depression

Depression, also known as major depressive disorder, is a medical condition associated with negative emotional, behavioural, and cognitive symptoms. Here is the latest research on this mood disorder.

Neurocognition and Behaviour

This feed focuses on neurobehavioral manifestations, neurocognitive development, and cognition disorders. Here is the latest research.

Signal Transduction & Gene Expression (Keystone)

Tumor cells have their own unique signal transduction and gene expression control. Targeting these specific cellular mechanisms and genetic proflies of cancer cells is an area of therapeutic exploration for some cancers. Discover the latest research on this topic with this feed.

Histone Deacetylases (Keystone)

Histone deacetylases (HDACs) are a class of chromatin-modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research on HDACs including SIRT6.

Dementia & Neurodegenerative Diseases

This feed focuses on the impact of insulin resistance, caloric restriction, cytokine singling, and metabolism on dementia and neurodegenerative diseases. Here is the latest research in this domain.

ALS

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Post-Traumatic Stress Disorder

Post Traumatic Stress Disorder (PTSD) occurs after a person has been exposed to a traumatic event involving actual or threatened death. Discover the latest research on PTSD here.

Cytokine Signaling & Transcription

Cytokines are proteins that are released by a subset of immune cells and play a role in intercellular communication, cell proliferation, differentiation, and survival. Discover the latest research on the influence of cytokine signaling on transcription here.

NK Cells

NK cells identify and attack target cells based on integration of signals from activation and inhibitory receptors, whose ligands exhibit complex expression and/or binding patterns. Here is the latest research.


PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR signal transduction pathway is crucial for cell cycle, thus directly regulates cell proliferation, longevity, and cancer. Here is the latest research on this intracellular signaling pathway.

Neuronal Guidance: Evolution

This feed focuses on mechanisms that underlie the evolution of axonal guidance pathways, neurogenesis, and synaptic connectivity. Here is the latest research.

Parkinson's Disease: Diagnostics and Clinical Trials

Parkinson’s disease (PD) is a neurodegenerative disorder that affects movement. This feed focuses on therapeutic aspects, diagnostic tools including medical imaging, and clinical trials in PD.

Alzheimer's Disease: Transcription

Transcription involves copying (transcribing) the gene's DNA sequence into RNA. Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and this disease.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Mammalian Cell Cycle & Cell Growth Control

Mammalian cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of mammalian cell cycle and growth.

Parkinson's Disease: Alpha-Synuclein

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.

Phenylketonuria (PKU)

Phenylketonuria (PKU) is an autosomal recessive disorder characterized by abnormalities in amino acid metabolism caused as a result of deficiency in phenylalanine hydroxylase, an enzyme that converts phenylalanine to tyrosine. Here is the latest research.

Phenylketonuria

Phenylketonuria (PKU) is an inborn error of metabolism that results from a deficiency of phenylalanine hydroxylase (PAH). Discover the latest research on phenylketonuria here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at a much more rapid rate. In MS it has been shown that there is a reduction in synaptic density, which is a potential area to target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Multiple Sclerosis

Multiple Sclerosis is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Discover the latest research on Multiple Sclerosis here.

Immunogenetics of Multiple Sclerosis

Multiple sclerosis (MS) was one of the first conditions shown to be associated with HLA class II factors. Find the latest research on MS here, including HLA studies providing insights on the genetics of the susceptibility to MS.

Hippocampal Neurogenesis

Hippocampal neurogenesis is the formation of new neurons from neural progenitor cells in the dentate gyrus. This is important for behavioural responses, learning and memory. Here is the latest research on hippocampal neurogenesis.

Neuronal and Network Dysfunction In Neurodegeneration

This feed focuses on neuronal and network dysfunction in neurodegenerative disorders and the effects of tauopathies on synapses and memory.

Histone Deacetylases

Histone deacetylases (HDACs) are a class of chromatin modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research. 


Related Papers

Brain, Behavior, and Immunity

A pilot study of immune network remodeling under challenge in Gulf War Illness

Brain, Behavior, and ImmunityOctober 20, 2010
Gordon BroderickNancy Klimas
BMC Medical Genomics

Impaired immune function in Gulf War Illness

BMC Medical GenomicsMarch 7, 2009
Toni WhistlerNancy Klimas
© 2020 Meta ULC. All rights reserved

Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis

Brain, Behavior, and Immunity

Dec 4, 2012

Gordon BroderickNancy Klimas

PMID: 23201588

DOI: 10.1016/j.bbi.2012.11.007

Abstract

Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating illness presenting with a complex constellation of immune, endocrine and neurological symptoms. Here we compared male GWI (n=20) with healt...read more

Mentioned in this Paper

Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Lymphocytosis
ZBTB16 gene
Immune Response
Active brand of pseudoephedrine-triprolidine
Flow Cytometry
Neurotrophic Tyrosine Kinase Receptor Type 2
Biochemical Pathway
Microarray Analysis
4
5
60

Similar Papers Found In These Feeds

Nervous System in C. elegans

Here is the latest research on structures and gene circuits in the nervous system of model organism C. Elegans.

Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Related Papers

Brain, Behavior, and Immunity

A pilot study of immune network remodeling under challenge in Gulf War Illness

Brain, Behavior, and ImmunityOctober 20, 2010
Gordon BroderickNancy Klimas
BMC Medical Genomics

Impaired immune function in Gulf War Illness

BMC Medical GenomicsMarch 7, 2009
Toni WhistlerNancy Klimas
Paper Details
References
  • References88
  • Citations19
12345...
  • References88
  • Citations19
12
/papers/altered-immune-pathway-activity-under-exercise/23201588