PMID: 9182682Jun 16, 1997Paper

Altered immune responses in interleukin 10 transgenic mice

The Journal of Experimental Medicine
A HagenbaughM Kronenberg

Abstract

Interleukin (IL)-10 is a pleiotropic cytokine which inhibits a broad array of immune parameters including T helper cell type 1 (Th1) cytokine production, antigen presentation, and antigen-specific T cell proliferation. To understand the consequences of altered expression of IL-10 in immune models of autoimmune disease, the response to infectious agents, and the response to tumors, we developed transgenic mice expressing IL-10 under the control of the IL-2 promoter. Upon in vitro stimulation, spleen cells from unimmunized transgenic mice secrete higher levels of IL-10 and lower amounts of IFN-gamma than do controls, although no gross abnormalities were detected in lymphocyte populations or serum Ig levels. Transfer of normally pathogenic CD4(+) CD45RBhigh splenic T cells from IL-10 transgenic mice did not cause colitis in recipient severe combined immunodeficiency mice. Furthermore, co-transfer of these transgenic cells with CD4(+) CD45RBhigh T cells from control mice prevented disease. Transgenic mice retained their resistance to Leishmania major infection, indicating that their cell-mediated immune responses were not globally suppressed. Lastly, in comparison to controls, IL-10 transgenic mice were unable to limit the growth o...Continue Reading

References

Apr 1, 1992·Genetical Research·A MonclaM M Portier
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HsiehK M Murphy
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Oct 1, 1991·Immunological Reviews·T R MosmannD F Fiorentino
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jan 1, 1995·Annual Review of Immunology·S L Reiner, R M Locksley
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Dec 1, 1994·Cellular Immunology·L WangR I Tepper
Jan 1, 1993·Annual Review of Immunology·K W MooreT R Mosmann
May 1, 1993·The Journal of Experimental Medicine·L E MinasiR A Flavell
Apr 18, 1996·Nature·K TakedaS Akira
Jul 1, 1996·The Journal of Experimental Medicine·N J DavidsonD M Rennick
Sep 1, 1996·The Journal of Experimental Medicine·M KopfW Solbach

❮ Previous
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Citations

Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·C Asselin-PaturelF Mami-Chouaib
Feb 10, 2000·Springer Seminars in Immunopathology·S Fowler, F Powrie
Aug 24, 1999·Medical Oncology·F Salazar-Onfray
Jan 13, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Heather A Arnett, Joanne L Viney
Sep 16, 2011·Cancer Immunology, Immunotherapy : CII·Cailin Moira WilkeWeiping Zou
Jun 3, 2005·Springer Seminars in Immunopathology·Hilde Cheroutre, Mitchell Kronenberg
Jan 4, 2006·Archives of Dermatological Research·Lisa J MaLaurie B Owen
Apr 3, 2012·Immunologic Research·Keren Rabinowitz, Lloyd Mayer
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Jan 27, 2004·Journal of Neuroimmunology·Brian GardnerSherven Sharma
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Michael P FischbeinAbbas Ardehali
Apr 6, 1999·Pharmacology & Therapeutics·P Hersey
Jun 7, 2003·Journal of Autoimmunity·Oliver AnnackerFiona Powrie
Sep 21, 2001·Microbes and Infection·C Toms, F Powrie
Apr 18, 2002·Microbes and Infection·Oliver Annacker, Fiona Powrie
Nov 8, 2002·Parasitology International·Alexandra Viana da CostaClaudie Verwaerde
Aug 10, 2002·Allergy·C B Schmidt-Weber, K Blaser
Aug 18, 2010·Immunology and Cell Biology·Antonio E SerranoMaría-Carmen Molina
Dec 12, 2001·The British Journal of Surgery·B SinghN J Mortensen
Oct 29, 1998·British Journal of Haematology·C PastoreG Saglio
May 13, 1999·Parasite Immunology·R ChatelainR L Coffman
Jun 5, 2002·The Journal of Experimental Medicine·Philippe PoussierMichael Julius
Feb 25, 2005·The Journal of Experimental Medicine·Roland GrenninglohI-Cheng Ho
Oct 13, 2006·Current Opinion in Gastroenterology·Y Ohtsuka, I R Sanderson
Aug 7, 2003·Inflammatory Bowel Diseases·Atsushi MizoguchiAtul K Bhan
May 18, 2011·Infection and Immunity·Joshua C Cyktor, Joanne Turner
Mar 24, 2005·Infection and Immunity·Laurence U Buxbaum, Phillip Scott
Dec 1, 1999·Annals of the Rheumatic Diseases·E W St Clair
Mar 24, 2009·Annual Review of Immunology·Ana IzcueFiona Powrie
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Apr 25, 2000·Annual Review of Medicine·K A Papadakis, S R Targan
Dec 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Fernanda R C GiachiniRita C Tostes
Nov 30, 2011·Cancer Research·Takashi TanikawaWeiping Zou

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