PMID: 8592058Jan 1, 1996Paper

Altered insulin-like growth factor-II (IGF-II) level and IGF-binding protein-3 (IGFBP-3) protease activity in interstitial fluid taken from the skin lesion of psoriasis

The Journal of Investigative Dermatology
S XuJeff M Holly

Abstract

In the present study, we have investigated insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in serum and artificially raised blister fluid from uninvolved and involved areas of nine patients with psoriasis. Both levels of IGFs and IGFBP-3, and profiles of IGFBP in serum and fluid from the uninvolved areas of these patients were comparable to those seen in normal subjects. In fluid from the involved areas, the IGF-II but not IGF-I level was significantly elevated. Among five molecular forms of IGFBP, the density of 41.5- and 38.5-kDa forms of IGFBP-3 were apparently increased in fluid from the involved areas, shown by Western ligand blotting. Radioimmunoassay further showed that the IGFBP-3 concentration in the involved areas was significantly raised. Immunoblotting revealed that the predominant form of IGFBP-3 in fluid from the uninvolved areas was a 29-kDa proteolytically modified product. In contrast, intact doublet IGFBP-3 was the main form of IGFBP-3 in fluid from the involved areas. Fluid from the involved areas but not the matched serum concentration-dependently inhibited the degradation of 125I-labeled nonglycosylated IGFBP-3 (ngIGFBP-3) caused by fluid from the uninvolved areas, suggesting the pres...Continue Reading

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Citations

Sep 1, 1996·Arthritis and Rheumatism·J K FernihoughJ M Holly
Dec 14, 2007·Clinical and Experimental Dermatology·S FieldB Kirby
Dec 13, 2003·Endocrine Reviews·Stephanie R EdmondsonChristopher J Wraight
Nov 11, 2008·Journal of Mammary Gland Biology and Neoplasia·D J FlintG J Allan
Jul 22, 2010·International Journal of Cosmetic Science·Y Sugiyama-NakagiriT Kitahara
May 18, 2010·The Journal of Rheumatology·Anne-Marie TobinBrian Kirby
Mar 23, 2006·Archives of Dermatological Research·Elisabeth Björntorp MarkAnders Lindahl
Aug 12, 1998·American Journal of Respiratory Cell and Molecular Biology·J T AllenM A Spiteri
Aug 17, 2019·Cells·Eliot Osher, Valentine M Macaulay
Jul 13, 2001·Pharmacology & Therapeutics·C J Wraight, P J White
Aug 10, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·L A MaileJ M Holly
Aug 12, 2004·The Journal of Investigative Dermatology·Hye Jung Kim, Tae-Yoon Kim
Nov 5, 1997·The Journal of Investigative Dermatology·E BjörntorpA Lindahl

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