Altered interferon-γ response in patients with Q-fever fatigue syndrome

The Journal of Infection
Stephan P KeijmelMarcel van Deuren

Abstract

Whether immunological mechanisms underlie Q-fever fatigue syndrome (QFS) remains unclear. For acute Q-fever, the antigen-specific interferon-γ (IFNγ) response may be a useful tool for diagnosis, and the IFNγ/interleukin(IL)-2 production ratio may be a marker for chronic Q-fever and treatment monitoring. Here we explored the specific IFNγ production and IFNγ/IL-2 ratio in QFS patients. IFNγ and IL-2 production were tested in ex-vivo stimulated whole blood of QFS patients (n = 20), and compared to those previously determined in seropositive controls (n = 135), and chronic Q-fever patients (n = 28). Also, the correlation between patient characteristics and IFNγ, IL-2, and IFNγ/IL-2 ratio was determined. QFS patients were younger (p < 0.001), but gender distribution was similar to seropositive controls and chronic Q-fever patients. Coxiella burnetii Nine Mile stimulation revealed a higher IFNγ production in QFS (median 319.5 pg/ml) than in seropositive controls (120 pg/ml, p < 0.01), but comparable to chronic Q-fever (2846 pg/ml). The IFNγ/IL-2 ratio was similar to that in seropositive controls, but lower than in chronic Q-fever patients (p < 0.01). Symptom duration was positively correlated with IL-2 production, and negatively cor...Continue Reading

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Citations

Aug 1, 2019·Open Forum Infectious Diseases·Ruud Ph RaijmakersStephen R Graves
Mar 4, 2020·International Journal of Environmental Research and Public Health·Christos BaliatsasJoris Yzermans
Aug 9, 2020·Frontiers in Microbiology·Soraya MezouarYassina Bechah
Nov 28, 2020·Journal of Translational Medicine·Ruud P H RaijmakersCheng-Jian Xu
Feb 7, 2019·Médecine et maladies infectieuses·Cléa MelenotteDidier Raoult

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