Altered interhemispheric functional coordination in chronic tinnitus patients

BioMed Research International
Yu-Chen ChenGao-Jun Teng

Abstract

Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered...Continue Reading

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Citations

Jul 28, 2016·Frontiers in Aging Neuroscience·Yu-Chen ChenXindao Yin
Nov 19, 2015·Frontiers in Neural Circuits·Yu-Chen ChenGao-Jun Teng
Mar 21, 2018·Frontiers in Aging Neuroscience·Yuan FengXindao Yin
Feb 9, 2017·Frontiers in Human Neuroscience·Yu-Chen ChenXindao Yin

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Software Mentioned

DPARSF
AFNI AlphaSim
REST
VMHC
Data Processing Assistant for Resting - State fMRI ( DPARSF )

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