Altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus

Neural Plasticity
Yu-Chen ChenGao-Jun Teng

Abstract

Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n = 29) with normal hearing and well-matched healthy controls (n = 30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r = 0.459, P = 0.012 and r = 0.479, P = 0.009, resp.). Chronic tinnitus patients showed abnormal intra- and int...Continue Reading

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Citations

Jul 28, 2016·Frontiers in Aging Neuroscience·Yu-Chen ChenXindao Yin
Nov 19, 2015·Frontiers in Neural Circuits·Yu-Chen ChenGao-Jun Teng
Feb 9, 2017·Frontiers in Human Neuroscience·Yu-Chen ChenXindao Yin
Mar 13, 2020·Frontiers in Human Neuroscience·Shirui ChengFanrong Liang
Jun 17, 2020·Frontiers in Neuroscience·Xiaofeng LinNingyi Jiang
Mar 21, 2018·Frontiers in Aging Neuroscience·Yuan FengXindao Yin
Aug 15, 2018·BioMed Research International·Ming-Chuan TsaiYan-Hong Chen
Apr 19, 2019·Trends in Hearing·Anthony GentilFrédéric Venail
Jan 16, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Theresa M MarschallIris E C Sommer

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Software Mentioned

SPSS
Data Processing Assistant for
ReHo
REST
BrainNet viewer
VBM8

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