Altered ionic calcium and cell motion in ventricular myocytes after cutaneous thermal injury

The Journal of Surgical Research
U S KoshyJ W Horton

Abstract

Cutaneous thermal injury resulting in burns covering approximately 45% of the total body surface area initiates metabolic alterations which contribute to subsequent myocardial dysfunction. Alterations in calcium homeostasis have been proposed as one mechanism by which burn injury alters organ function. This study used fura-2 and time-resolved single cell fluorescence microscopy to examine stress-related alterations in intracellular calcium in isolated adult rat cardiac myocytes. Ventricular myocytes were isolated from rats given a full-thickness scald burn comprising 43% of the total body surface area and fluid resuscitated with lactated Ringer's by the Parkland formula; control animals were included for comparison. Burn trauma caused a significant increase in cardiac myocyte maximal (peak systolic) and minimal (diastolic) mean cytosolic free calcium concentration ([Ca2+]i) transient ratios when compared to [Ca2+]i transient ratios measured in control rats. Isoproterenol application altered the time course of the [Ca2+]i transients of normal myocytes but this response was not observed in myocytes from the thermally injured rats. In addition, isoproterenol application to normal myocytes produced a significant increase in the amp...Continue Reading

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Citations

Jan 6, 2016·International Journal of Molecular Sciences·Ashley N GuilloryCeleste C Finnerty
Apr 2, 2008·Burns : Journal of the International Society for Burn Injuries·Z BakB Janerot-Sjoberg
Mar 24, 2004·Redox Report : Communications in Free Radical Research·Bing-Xing PanKe-Seng Zhao
Oct 21, 1999·The Journal of Surgical Research·J W HortonB Giroir
Mar 14, 1998·The Journal of Trauma·J W HortonD Maass
Mar 21, 2002·Critical Care Medicine·D Jean WhiteJureta W Horton
Oct 11, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Atsuko YataniEdwin A Deitch
Feb 26, 1998·Journal of Applied Physiology·J W HortonB Sanders
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Z F XiaJ W Horton
Jan 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kentaro KawaiAtsuko Yatani
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Deborah L CarlsonBrett P Giroir
Dec 13, 2017·PloS One·Ashley N GuilloryCeleste C Finnerty
Jul 21, 2000·Annals of Clinical Biochemistry·Y N ChenZ Y Lin

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