Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.

The Journal of Biological Chemistry
Bronwen MartinStuart Maudsley

Abstract

The type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perception. Besides the tongue, the T1R3 receptor is highly expressed in brain areas implicated in cognition, including the hippocampus and cortex. As cognitive decline is often preceded by significant metabolic or endocrinological dysfunctions regulated by the sweet-taste perception system, we hypothesized that a disruption of the sweet-taste perception in the brain could have a key role in the development of cognitive dysfunction. To assess the importance of the sweet-taste receptors in the brain, we conducted transcriptomic and proteomic analyses of cortical and hippocampal tissues isolated from T1R3 knock-out (T1R3KO) mice. The effect of an impaired sweet-taste perception system on cognition functions were examined by analyzing synaptic integrity and performing animal behavior on T1R3KO mice. Although T1R3KO mice did not present a metabolically disrupted phenotype, bioinformatic interpretation of the high-dimensionality data indicated a strong neurodegenerative signature associated with significant alterations in pathways involved in neuritogenesis, dendritic growth, and synaptogenesis. Furthermore, a significantly reduced dend...Continue Reading

References

Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Dec 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·S NagaokaR Inoue
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FengP Greengard
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·J S SnowdenD Neary
Feb 5, 2002·Annual Review of Physiology·Esther A NimchinskyKarel Svoboda
Feb 13, 2002·Chemical Senses·John D BoughterDavid V Smith
Jul 12, 2002·Behavioural Brain Research·Makoto MizunoToshitaka Nabeshima
Nov 11, 2003·Genes, Brain, and Behavior·J L R Rubenstein, M M Merzenich
Nov 25, 2003·Chemical Senses·Theodore M NelsonJohn D Boughter
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Mar 23, 2004·Journal of Cellular Biochemistry·K HeeseT Sawada
Jun 11, 2004·Nature·Masanori MatsuzakiHaruo Kasai
Jul 6, 2004·Annals of Neurology·Stefan KnechtE Bernd Ringelstein
Aug 10, 2004·The Journal of Biological Chemistry·Peihua JiangMarianna Max
Oct 8, 2004·Development·Kyuson YunMark A Israel
Dec 21, 2004·Nature Neuroscience·Silvana B RossoPatricia C Salinas
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dario BonanomiFlavia Valtorta
Sep 17, 2005·Journal of Neuroimmunology·Lidia SabaterFrancesc Graus
Oct 6, 2005·Genes & Development·Baris TursunIngolf Bach
Apr 7, 2006·Nature Medicine·Stuart Maudsley, Mark P Mattson
Dec 22, 2006·Journal of Alzheimer's Disease : JAD·D Allan ButterfieldRalph N Martins
Jan 24, 2007·Nature Reviews. Neuroscience·Victor A DerkachThomas R Soderling
Jan 30, 2007·Neuroreport·Fernando A BarriosJuan Fernandez-Ruiz
Feb 7, 2007·Annual Review of Neuroscience·Veronica A Alvarez, Bernardo L Sabatini
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher S RexGary Lynch

❮ Previous
Next ❯

Citations

Dec 7, 2018·Nature Reviews. Drug Discovery·Sung-Joon LeeHanns Hatt
Feb 4, 2019·Journal of Neuroendocrinology·Maik Behrens, Wolfgang Meyerhof
Jan 9, 2019·Frontiers in Pharmacology·Jhana O HendrickxStuart Maudsley
Aug 31, 2019·Nutrients·Ryan M Carey, Robert J Lee
Dec 14, 2018·Frontiers in Physiology·Nicholas M DalesioDan E Berkowitz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2022 Meta ULC. All rights reserved