Altered left ventricular diastolic properties during pacing-induced angina in patients with aortic stenosis

Circulation
M A FiferB H Lorell

Abstract

An increase in left ventricular diastolic pressure has been repeatedly observed during angina in patients with coronary artery stenoses and regional demand ischemia, but the role of relaxation abnormalities versus left ventricular segmental dyssynchrony is controversial. In contrast, patients with angina due to aortic stenosis are likely to have diffuse rather than segmental ischemia and thus may provide an alternative model for examining the diastolic physiology of angina in man. Accordingly, we examined the hemodynamic manifestations of angina in eight patients with aortic stenosis without significant coronary artery disease. Angina was induced by pacing tachycardia, and hemodynamic and echocardiographic variables were measured in the control period and during angina in the beats immediately after cessation of pacing. Heart rate (control vs angina, 69 +/- 12 vs 70 +/- 11 beats/min, p = NS) and left ventricular peak systolic pressure (207 +/- 39 vs 222 +/- 22 mm Hg, p = NS) were similar in the control and postpacing angina periods. Left ventricular end-diastolic pressure, on the other hand, was significantly higher during postpacing angina (15 +/- 7 vs 28 +/- 8 mm Hg, p less than .01). The time constant of left ventricular pre...Continue Reading

References

Nov 1, 1973·The American Journal of Cardiology·L P McLaurinW Grossman
Jan 1, 1984·Circulation·D L BrutsaertS U Sys
Dec 1, 1954·A.M.A. Archives of Internal Medicine·J BERGERONL B ELLIS

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Citations

May 1, 1989·Journal of the American College of Cardiology·W H Abelmann, B H Lorell
Aug 1, 1992·Journal of the American College of Cardiology·P BrunJ L Dubois-Rande
May 1, 1987·Journal of the American College of Cardiology·B H Lorell, W Grossman
Nov 28, 1991·The New England Journal of Medicine·W Grossman
Jul 22, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Toshiaki TarumiTetsu Yamakado
Jan 1, 1990·Annals of the New York Academy of Sciences·M B Waxman, D A Cameron
Jan 1, 1995·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·C L SimekS Kaul
Feb 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M I MiyamotoM H Picard
Dec 1, 1988·Journal of Cardiac Surgery·C S Apstein, B H Lorell
Oct 15, 1992·Hospital Practice·B H Lorell

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