Altered left ventricular performance in aging physically active mice with an ankle sprain injury

Age
Michael J TurnerTricia Hubbard-Turner

Abstract

We assessed the impact of differing physical activity levels throughout the lifespan, using a musculoskeletal injury model, on the age-related changes in left ventricular (LV) parameters in active mice. Forty male mice (CBA/J) were randomly placed into one of three running wheel groups (transected CFL group, transected ATFL/CFL group, SHAM group) or a SHAM Sedentary group (SHAMSED). Before surgery and every 6 weeks after surgery, LV parameters were measured under 2.5 % isoflurane inhalation. Group effects for daily distance run was significantly greater for the SHAM and lesser for the ATLF/CFL mice (p = 0.013) with distance run decreasing with age for all mice (p < 0.0001). Beginning at 6 months of age, interaction (group × age) was noted with LV posterior wall thickness-to-radius ratios (h/r) where h/r increased with age in the ATFL/CFL and SHAMSED mice while the SHAM and CFL mice exhibited decreased h/r with age (p = 0.0002). Passive filling velocity (E wave) was significantly greater in the SHAM mice and lowest for the ATFL/CFL and SHAMSED mice (p < 0.0001) beginning at 9 months of age. Active filling velocity (A wave) was not different between groups (p = 0.10). Passive-to-active filling velocity ratio (E/A ratio) was diffe...Continue Reading

References

Dec 1, 1991·Foot & Ankle·J W PetersP A Renstrom
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Nov 1, 1986·The American Journal of Sports Medicine·R W Smith, S F Reischl
Jul 1, 1966·Journal of Gerontology·J B Storer
Mar 1, 1984·Clinical Orthopaedics and Related Research·S H SoboroffA L Komaroff
Jan 1, 1995·Archives of Orthopaedic and Trauma Surgery·R A VerhagenC N van Dijk
Mar 4, 2000·Circulation Research·S MiyataL A Leinwand
Aug 5, 2000·Clinics in Geriatric Medicine·D W Kitzman
Aug 10, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T TillmannU Mohr
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P J ReiserC Schomisch Moravec
Dec 6, 2001·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A D Waggoner, S M Bierig
Jul 15, 2003·Journal of Applied Physiology·Ali A EhsaniJohn O Holloszy
Sep 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Julie R McMullenSeigo Izumo
Feb 10, 2004·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kazuya HiroseToshihiko Yamashita
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ben J A JanssenThomas L Smith
Sep 24, 2004·Physiological Genomics·J Timothy LightfootSteven R Kleeberger
Apr 28, 2005·Physiological Genomics·Michael J TurnerJ Timothy Lightfoot
Nov 24, 2005·The American Journal of Sports Medicine·Victor ValderrabanoTak Shing Fung
Oct 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kumar PandyaOliver Smithies
Jan 26, 2007·Mechanisms of Ageing and Development·Jun RenSara A Babcock
May 22, 2007·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·William G FernandezR Dawn Comstock
Jan 4, 2008·Physiological Genomics·J Timothy LightfootLarry J Leamy
Oct 9, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leanne GrobanWilliam Sonntag
May 20, 2009·Circulation·Dao-Fu DaiPeter S Rabinovitch
Jul 22, 2009·Physiology & Behavior·Amy M KnabJ Timothy Lightfoot
Oct 10, 2009·Journal of Science and Medicine in Sport·Véronique A CornelissenPaul J Lijnen
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Amy D BradshawMichael R Zile
Apr 13, 2010·Trends in Cardiovascular Medicine·Dao-Fu Dai, Peter S Rabinovitch
Sep 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Craig A Emter, Christopher P Baines
Jan 26, 2012·Scandinavian Cardiovascular Journal : SCJ·Harald Edvard MolmenCharlotte Bjork Ingul
Mar 10, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S-D LeeC-Y Huang

❮ Previous
Next ❯

Citations

Feb 8, 2018·Journal of Athletic Training·Erik A WikstromMichael J Turner
Jun 12, 2019·Journal of Athletic Training·Jennifer M Medina McKeon, Matthew C Hoch
Jul 26, 2019·Journal of Athletic Training·Erik A WikstromMichael J Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.