Altered left ventricular twist is associated with clinical severity in adults and adolescents with homozygous sickle cell anemia

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Joao Carlos Moron Saes BragaDanielen Cristina Mariano Peluccio

Abstract

Sickle cell anemia (SCA) is associated with cardiac abnormalities and premature death. The aims of this study were to identify early markers of cardiac dysfunction through ventricular strain and ventricular twist and determine the relationships between these measures and other markers of cardiovascular risk. Forty patients with SCA (mean age, 23.5 ± 9.3 years; 24 male patients) and 40 age- and sex-matched healthy individuals were compared. All subjects participated in structured interviews, and blood samples were collected. Standard echocardiography with subsequent offline evaluations using left ventricular (LV) and right ventricular systolic strain and rotational analyses of the left ventricle using two-dimensional speckle-tracking echocardiography were performed. There were no differences in LV ejection fraction, global LV strain (longitudinal, circumferential, and radial), and global right ventricular longitudinal strain between patients and controls; however, LV twist was significantly lower in the patient group (mean, 7.4 ± 1.2° vs 10.7 ± 1.8°; P < .0001). Several variables were strongly related to LV twist, including the clinical severity index (ρ = -0.97, Z score = -6.05, P < .0001), E/e' ratio (r = 0.78, P < .0001), LV ...Continue Reading

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Citations

Nov 20, 2018·British Journal of Haematology·Nicholas S WhippleJane S Hankins
Dec 14, 2018·Frontiers in Medicine·Aymeric MenetXavier Jouven
Jul 6, 2020·The International Journal of Cardiovascular Imaging·Maria Betânia Solis ResendeMaria Carmo Pereira Nunes
Mar 21, 2021·Pediatric Blood & Cancer·Nicholas S WhippleJane S Hankins

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