Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Veer GuptaAIBL Research Group

Abstract

A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P = .0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P = .0008). These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts.

References

Jan 22, 1977·Lancet·T E AdrianR C Russell
Dec 16, 1978·Lancet·G R GreenbergS R Bloom
Mar 1, 1978·The Journal of Clinical Investigation·T W SchwartzF Stadil
May 8, 1992·Brain Research·P L McGeerD G Walker
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D Miller, M S Krangel
Jun 5, 1990·Biochemistry·H V de SilvaJ Robbins
Mar 29, 1991·Biochemical and Biophysical Research Communications·S BettuzziC Franceschi
Nov 1, 1989·The Journal of Immunology : Official Journal of the American Association of Immunologists·M D MillerM S Krangel
Aug 31, 1987·Biochemical and Biophysical Research Communications·J G LégerM P Tenniswood
Apr 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J MarcoM L Villanueva
Jun 1, 1980·Diabetes·V LassmannM C Simon
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·J G ZangrilliS P Peters
Nov 15, 1994·Biochemical and Biophysical Research Communications·T OdaC E Finch
Sep 8, 1993·Molecular and Cellular Biochemistry·Y S LiP E Kolattukudy
Apr 1, 1993·Journal of Neurobiology·M K O'BryanM J Pearse
Jul 11, 1997·The Journal of Biological Chemistry·R S RoosB Moser
Oct 23, 1997·Protein Science : a Publication of the Protein Society·J T KapronJ W Crabb
Jan 10, 1998·The Biochemical Journal·D MichelG Brun
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·Y NakashimaR Ross
Apr 9, 1999·Nature Neuroscience·K B ClarkR A Jensen
Nov 26, 2002·The Journal of Clinical Psychiatry·Magnus J C SjögrenElinor Ben-Menachem
Apr 13, 2004·Nature Medicine·Yong QiRexford S Ahima
Jul 21, 2004·International Journal of Cardiology·Umit GürayEmine Kütük
Sep 17, 2004·Biochemical and Biophysical Research Communications·Anna M WolfHerbert Tilg
Oct 12, 2007·Brain : a Journal of Neurology·Kerryn E PikeChristopher C Rowe

❮ Previous
Next ❯

Citations

Oct 13, 2017·Expert Review of Neurotherapeutics·Kurt A Jellinger
Nov 11, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Belinda M BrownJeremiah J Peiffer
Nov 12, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter D FransquetJoanne Ryan
Jan 17, 2020·Current Pharmaceutical Design·Patricia Regina ManzineMarcia Regina Cominetti
Sep 6, 2019·Medicines·Patricia ReganMargaret Doherty
Jun 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Junghee HaEosu Kim
Sep 6, 2020·Journal of Neurochemistry·Steve PedriniRalph N Martins
May 13, 2018·Neurología : publicación oficial de la Sociedad Española de Neurología·M Altuna-Azkargorta, M Mendioroz-Iriarte

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCRs
glycosylation

Software Mentioned

R
R Language Environment

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Kazuhiko UchidaTakashi Asada
Journal of Alzheimer's Disease : JAD
Wayne R LeifertAustralian Imaging, Biomarkers and Lifestyle Study Research Group
© 2022 Meta ULC. All rights reserved