Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue

International Journal of General Medicine
Ellen Johanne VaraG A Lied

Abstract

A considerable number of patients with gastrointestinal complaints attributable to irritable bowel syndrome (IBS) have shown evidence of immune activation. Fatigue is also frequently reported by IBS patients and the condition is considered as a common comorbidity of IBS. Therefore, it is interesting to see whether these two conditions share the same pathophysiological mechanism. To investigate the potential role of cytokine profiles in patients with IBS and the relationship between cytokine profiles and fatigue. Thirty-eight patients with IBS (32 females, 6 males, age range 18-70 years) and 22 healthy individuals (control group) (17 females, 5 males, age range 24-42 years) were included. IBS was diagnosed according to Rome III criteria, and severity of IBS symptoms and fatigue were evaluated using the Irritable Bowel Syndrome-Severity Scoring System (IBS-SSS) and Fatigue Impact Scale (FIS), respectively. FIS scores of 25 or higher were defined as fatigue. Blood samples were also taken, and the Luminex® platform (Cytokine Human Ultrasensitive Magnetic 10-Plex Panel) was used for quantifying human cytokines' profile (granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin [IL]-1β, IL-2, IL-4, IL-5, IL-6, IL-8,...Continue Reading

Citations

Jul 14, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pasquale MansuetoAntonio Carroccio
Jul 24, 2020·Pakistan Journal of Biological Sciences : PJBS·Lienda Bashier EltayebHisham Ali Waggiallah
Aug 29, 2018·Journal of Clinical Medicine·Stephanie BalikjiJoris C Verster
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Caterina CarcoNicole C Roy
Nov 30, 2020·Brain, Behavior, and Immunity·Anna-Karin NorlinMaria Engström
Jul 27, 2021·Gastroenterology Clinics of North America·Elizabeth J Videlock, Lin Chang
Aug 10, 2021·Beneficial Microbes·E Arvidsson NordströmN Larsson
Nov 3, 2021·Journal of Clinical Pharmacy and Therapeutics·Sahar M El-HaggarMostafa M Bahaa
Dec 5, 2021·Clinical Journal of Gastroenterology·Sunil KumarAwanish Kumar

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