Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration

Journal of Neuropathology and Experimental Neurology
Caitlin M KirkwoodRobert A Sweet

Abstract

Recent studies have implicated the neuronal calcium-sensing protein visinin-like 1 protein (Vilip-1) as a peripheral biomarker in Alzheimer disease (AD), but little is known about expression of Vilip-1 in the brains of patients with AD. We used targeted and quantitative mass spectrometry to measure Vilip-1 peptide levels in the entorhinal cortex (ERC) and the superior frontal gyrus (SF) from cases with early to moderate stage AD, frontotemporal lobar degeneration (FTLD), and cognitively and neuropathologically normal elderly controls. We found that Vilip-1 levels were significantly lower in the ERC, but not in SF, of AD subjects compared to normal controls. In FTLD cases, Vilip-1 levels in the SF were significantly lower than in normal controls. These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of ERC neuron loss in AD.

References

Dec 1, 1996·Journal of Neuropathology and Experimental Neurology·P GiannakopoulosC Bouras
Mar 17, 2004·Annals of Internal Medicine·Clifford J WoolfUNKNOWN American Physiological Society
Apr 21, 2004·Annals of Internal Medicine·Dennis J SelkoeUNKNOWN American Physiological Society
Jan 12, 2005·Genome Biology·Leif Dehmelt, Shelley Halpain
Jul 20, 2005·Pharmaceutical Research·Conrad E JohansonAndrew Baird
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Jul 22, 2006·Clinical Chemistry·Omar F LaterzaJack H Ladenson
Jun 21, 2007·Acta Neuropathologica·Nigel J CairnsUNKNOWN Consortium for Frontotemporal Lobar Degeneration
Aug 9, 2007·Nature Reviews. Neuroscience·Carlo BallatoreJohn Q Trojanowski
Jun 7, 2011·Acta Neuropathologica·Ian R A MackenzieVirginia M Y Lee
Aug 9, 2011·Annals of Neurology·Rawan TarawnehDavid M Holtzman
Mar 21, 2012·Neurobiology of Aging·Patrick S MurrayRobert A Sweet
Jul 31, 2013·The American Journal of Psychiatry·Oscar L LopezWilliam E Klunk
Mar 5, 2014·International Psychogeriatrics·Anil Varma V VatsavayiRobert A Sweet
Mar 7, 2014·Science Translational Medicine·Anne M FaganUNKNOWN Dominantly Inherited Alzheimer Network

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Citations

Mar 6, 2019·Cold Spring Harbor Perspectives in Biology·Robert D BurgoyneLee P Haynes
Feb 17, 2019·Cellular and Molecular Life Sciences : CMLS·Kunal DhimanVeer Bala Gupta
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Feb 4, 2021·International Journal of Molecular Sciences·Shon A KorenJose F Abisambra

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