Altered lipid metabolism in the aging kidney identified by three layered omic analysis

Aging
Fabian BraunChristine E Kurschat

Abstract

Aging-associated diseases and their comorbidities affect the life of a constantly growing proportion of the population in developed countries. At the center of these comorbidities are changes of kidney structure and function as age-related chronic kidney disease predisposes to the development of cardiovascular diseases such as stroke, myocardial infarction or heart failure. To detect molecular mechanisms involved in kidney aging, we analyzed gene expression profiles of kidneys from adult and aged wild-type mice by transcriptomic, proteomic and targeted lipidomic methodologies. Interestingly, transcriptome and proteome analyses revealed differential expression of genes primarily involved in lipid metabolism and immune response. Additional lipidomic analyses uncovered significant age-related differences in the total amount of phosphatidylethanolamines, phosphatidylcholines and sphingomyelins as well as in subspecies of phosphatidylserines and ceramides with age. By integration of these datasets we identified Aldh1a1, a key enzyme in vitamin A metabolism specifically expressed in the medullary ascending limb, as one of the most prominent upregulated proteins in old kidneys. Moreover, ceramidase Asah1 was highly expressed in aged k...Continue Reading

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Citations

Oct 13, 2016·Frontiers in Molecular Biosciences·Vera SchützholdEdda Klipp
Feb 6, 2017·American Journal of Physiology. Renal Physiology·Tareq B MalasPeter A C 't Hoen
Jul 28, 2016·Zeitschrift für Gerontologie und Geriatrie·F Braun, P T Brinkkötter
Jul 18, 2019·Aging Cell·Gayoung LeeHunjoo Ha
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Qin-Li WanGui-Sheng Wu
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Feb 19, 2020·American Journal of Physiology. Renal Physiology·Suwen LiuSongming Huang
Mar 18, 2021·Aging Cell·Ruin MoaddelLuigi Ferrucci
Mar 31, 2021·Free Radical Biology & Medicine·Chien-Wei LeeOscar Kuang-Sheng Lee
Jul 25, 2021·International Journal of Molecular Sciences·Joanna Tracz, Magdalena Luczak
Aug 18, 2018·Journal of Proteome Research·Danielle B GutierrezRichard M Caprioli
Jun 28, 2019·Journal of Proteome Research·Sue Ah NohKwang Pyo Kim

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