Altered localization of p120 catenin in the cytoplasm rather than the membrane correlates with poor prognosis in esophageal squamous cell carcinoma

PloS One
Tian ChenGang Li

Abstract

P120 catenin (p120ctn), a regulator of cell adhesion, has previously been found in many malignancies, and suggested a role in invasion, metastasis and survival. The aim of this study was to investigate correlations between altered localization of p120ctn and clinical-pathological characteristics in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining for p120ctn was performed on tissue samples from 118 patients with ESCC. The expression of p120ctn was scored for intensity and cellular localization by Image-pro Plus 6.0. Correlations between immunohistochemical staining of p120ctn and pathological characteristics and clinical prognosis were determined using SPSS 18.0 software. Membrane expression of p120ctn in ESCCs was lower than that in adjacentnormal esophageal epithelial tissues (P = 0.041), while overall cellular expression of p120ctn was not different between the two tissue types (P = 0.787). Furthermore, neither overall cellular expression nor localized membrane expression was associated with histological and clinical variables. The high ratio of membrane expression to overall cellular expression (M/C) of p120ctn was inversely associated with lymph node invasion (P = 0.001), tumor differentiation (P = 0...Continue Reading

References

Aug 1, 1994·Cell Adhesion and Communication·J Stappert, R Kemler
Jan 12, 2000·The Journal of Cell Biology·M A ThoresonA B Reynolds
May 31, 2001·The Journal of Biological Chemistry·D J MarinerA B Reynolds
Jan 5, 2002·Oral Oncology·L Lo MuzioM A Mariggiò
Dec 21, 2002·Differentiation; Research in Biological Diversity·Molly A Thoreson, Albert B Reynolds
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Mar 23, 2004·Journal of Dermatological Science·Yasuko IshizakiKatsuhiko Enomoto
May 27, 2004·The American Journal of Pathology·Tatsuhiro ShibataSetsuo Hirohashi
Sep 15, 2004·Current Opinion in Cell Biology·Andrew P Kowalczyk, Albert B Reynolds
Sep 29, 2004·American Journal of Surgery·Mitsuo TachibanaNaofumi Nagasue
Oct 19, 2004·Oncogene·Albert B Reynolds, Agnes Roczniak-Ferguson
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 19, 2006·Biochimica Et Biophysica Acta·Albert B Reynolds
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shlomit BoguslavskyAlexander Bershadsky
Oct 10, 2007·BJU International·Brasil Silva NetoIan C Summerhayes
Jul 3, 2008·World Journal of Gastroenterology : WJG·Bo ZhaiHong-Yang Wang
Oct 28, 2008·Neoplasia : an International Journal for Oncology Research·Patrick E CorsinoBrian K Law
Feb 13, 2010·Journal of Cancer Research and Clinical Oncology·K TalvinenP Kronqvist
Jun 10, 2010·Nature Reviews. Drug Discovery·István PetákGyörgy Kéri
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 20, 2012·Molecular Biology of the Cell·Yuliya I PetrovaBarry M Gumbiner
Dec 14, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Shuli LiuEnhua Wang

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Citations

Oct 21, 2015·Biochimica Et Biophysica Acta·Ji Yeon HongPierre D McCrea
Mar 10, 2017·Critical Reviews in Biochemistry and Molecular Biology·Mireia DuñachAntonio García de Herreros
Jun 8, 2017·Acta Medica (Hradec Králové)·Vladimír Bartoš, Milada Kullová
Aug 11, 2015·Journal of Cellular and Molecular Medicine·Fujun YuJianjian Zheng
May 29, 2018·Technology in Cancer Research & Treatment·Qian Dong ZhuXia Deng
Aug 13, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ting WangLin Zou
Sep 25, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C NiuZ Fu
Jun 24, 2017·Molecular Cancer Research : MCR·Michal KidackiDouglas B Stairs

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Methods Mentioned

BETA
biopsy

Software Mentioned

IPP
SPSS
Image
pro Plus

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