Altered lung development after prenatal nicotine exposure in young lambs

Pediatric Research
Kenneth SandbergHakan W Sundell

Abstract

There is compelling evidence that prenatal nicotine exposure permanently alters lung development and airway function. The aim of this study was to determine how prenatal nicotine exposure alters proximal and distal airway function. Thirteen lambs were continuously exposed during the last fetal trimester to low-dose nicotine (LN) and 12 to a moderate dose (MN) (maternal s.c. dose: 0.5 and 1.5 mg/kg/d, respectively). Ten lambs served as controls (C). Proximal airway function was measured by lung mechanics. A multiple-breath N2 washout technique was used to measure lung volume (functional residual capacity) and efficiency of gas mixing in distal airways, i.e. terminal respiratory units (moment ratio and nitrogen clearance). In comparison with C, both LN and MN had significantly reduced specific airway conductance to the same extent at a median study age of 12, 25, and 51 d, indicating signs of proximal airway obstruction. Distal airway function showed significant improvement in LN. Ventilation and functional residual capacity were unaffected. In summary, prenatal nicotine exposure induced airway obstruction in proximal airways and improved gas mixing in distal airways, possibly reflecting restriction in proximal airway growth and ...Continue Reading

References

Jun 8, 1978·The New England Journal of Medicine·M CosioP T Macklem
May 1, 1992·The American Review of Respiratory Disease·J P HanrahanF E Speizer
Aug 1, 1991·Pediatric Research·K SandbergH W Sundell
Jul 1, 1987·Physiological Reviews·M Paiva, L A Engel
Jan 1, 1987·Acta paediatrica Scandinavica·K SandbergT Olsson
Jun 1, 1986·Obstetrics and Gynecology·J R LeibermanV Insler
Jan 1, 1986·Medical & Biological Engineering & Computing·B A SjöqvistT Olsson
Apr 1, 1985·Pediatric Research·M H CollinsW A Blanc
Mar 1, 1967·Journal of Applied Physiology·P T Macklem, J Mead
Oct 15, 1983·American Journal of Obstetrics and Gynecology·L B CuretW K Poole
Nov 1, 1983·Clinical Pharmacology and Therapeutics·N L BenowitzA L Osman
Jan 1, 1995·Pediatric Pulmonology. Supplement·J Mallol
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·I B TagerJ P Hanrahan
Apr 1, 1995·Obstetrics and Gynecology·S P CliverK G Nelson
Apr 1, 1993·The American Review of Respiratory Disease·I B TagerF E Speizer
Feb 25, 1998·Pediatric Pulmonology·H ShaoO Hjalmarson
Jun 2, 1998·American Journal of Respiratory and Critical Care Medicine·P T Macklem
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·A F HooJ Stocks
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M JonesR S Tepper
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·J ElliotP Robinson
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·H S SekhonE R Spindel
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Harmanjatinder S SekhonEliot R Spindel
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Ola Hjalmarson, Kenneth Sandberg
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Ola HafströmHåkan W Sundell
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·John G ElliotPhilip J Robinson

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Citations

Apr 7, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer E BruinAlison C Holloway
Jan 17, 2012·American Journal of Respiratory Cell and Molecular Biology·Cherry WongtrakoolEliot R Spindel
Oct 14, 2010·Experimental Lung Research·Shruti GuptaJ Craig Cohen
Jan 5, 2011·Respiratory Physiology & Neurobiology·Kenneth L SandbergHåkan W Sundell
Nov 23, 2006·Respiratory Physiology & Neurobiology·Kenneth L SandbergHåkan W Sundell
Jan 8, 2013·Acta Paediatrica·Kenneth L SandbergHåkan W Sundell
Jun 13, 2006·Paediatric Respiratory Reviews·Suhas G Kallapur, Machiko Ikegami
Aug 6, 2005·Early Human Development·Gert S MaritzRichard Harding
Jun 23, 2005·Respiratory Physiology & Neurobiology·Ola HafströmHåkan W Sundell
Aug 13, 2011·Molecular Genetics and Metabolism·Lisa A Joss-MooreRobert H Lane
Mar 8, 2012·Critical Reviews in Toxicology·Louise C Abbott, Ursula H Winzer-Serhan
Feb 8, 2007·Journal of Health Psychology·K H GinzelTheodore A Slotkin
Jan 12, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Virender K RehanJohn S Torday
Mar 10, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo ZhuangFadi Xu
Jan 23, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sanja BlaskovicConstance Barazzone-Argiroffo
Oct 4, 2019·Birth Defects Research·Katherine M Kuniyoshi, Virender K Rehan

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