Altered lymphocyte distribution in Alzheimer's disease

Journal of Psychiatric Research
Elke Richartz-SalzburgerKlaus Schott

Abstract

The contribution of immunological factors in the etiopathogenesis of Alzheimer's disease (AD) is increasingly noted. Apart from cerebral immunological findings, peripheral changes of the immune systems have been reported including lymphocyte function and subset distribution. As data still remain inconsistent, we investigated a sample of 43 patients with AD and of 34 healthy age-matched controls. Distribution of the T-, B- and NK cell subsets was determined by flow cytometry (FACS). We found a significant decrease of CD3(+) lymphocytes as well as of CD19(+) lymphocytes. A slight increase of the CD4(+) and a decrease of the CD8(+) subpopulation could be observed, without significant change of the CD4(+)/CD8(+) ratio. CD16(+)56(+) cells were not altered. Our findings of decreased T- and B-Cell numbers in AD sustain the hypothesis of a general decline of immune activity in AD. A putative association with premature immunosenescence in AD and possible pathogenetic implications are discussed.

Citations

Dec 11, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bruce J BrewGilles Guillemin
Jan 26, 2013·Epidemiologic Reviews·Francis Mawanda, Robert Wallace
Jul 31, 2013·Journal of Molecular Cell Biology·Gaëlle Naert, Serge Rivest
Feb 28, 2008·Dementia and Geriatric Cognitive Disorders·Ezra MulugetaPaul T Francis
Nov 19, 2008·Journal of Neuroinflammation·Brian GiuntaJun Tan
Sep 29, 2011·Molecular Neurodegeneration·Merav KedmiAvi Orr-Urtreger
Jun 7, 2013·PloS One·Niklas K U KoehlerElke Richartz-Salzburger
Aug 26, 2014·BMC Complementary and Alternative Medicine·Abilio Reig-FerrerNatalia Albaladejo-Blazquez
Jan 1, 2012·Longevity & Healthspan·Adriana MartoranaGiuseppina Colonna-Romano
Jan 19, 2016·Molecular Neurobiology·Erica LanaHomira Behbahani
Nov 27, 2007·Journal of Neuroimmunology·Konstantinos BonotisStavros Baloyannis
Feb 27, 2007·Journal of Psychiatric Research·Shino MagakiWolff M Kirsch
Aug 15, 2012·Scandinavian Journal of Immunology·F Jadidi-NiaraghA Mirshafiey
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Sofia SöllvanderDag Sehlin
Feb 28, 2015·Journal of Alzheimer's Disease : JAD·Aurélie Le PageTamás Fülöp
Apr 7, 2015·PloS One·Niklas K U KoehlerElke Richartz-Salzburger
Jan 24, 2017·International Journal of Geriatric Psychiatry·Fumihiko YasunoKazuyuki Nagatsuka
May 17, 2013·American Journal of Alzheimer's Disease and Other Dementias·Fatemeh Naddafi, Abbas Mirshafiey
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·Nicholas W S DaviesBruce J Brew
Jun 10, 2010·Nature Reviews. Neurology·Michal Schwartz, Ravid Shechter
Nov 12, 2009·Expert Review of Neurotherapeutics·Kavon Rezai-ZadehTerrence Town
Sep 10, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Masato MitsuhashiEdward J Goetzl
Sep 13, 2019·International Journal of Molecular Sciences·Li ZuoTingyang Zhou
Dec 20, 2012·Psychiatry Investigation·Misun SongDoh Kwan Kim
Oct 29, 2017·Molecular Neurodegeneration·Annika SommerIryna Prots
Jan 7, 2019·Journal of Neuroinflammation·Isabelle St-AmourFrédéric Calon
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·F CiccocioppoS Miscia
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Mandy BusseStefan Busse
Nov 27, 2018·Biochemistry. Biokhimii︠a︡·M P AliseychikE I Rogaev
Oct 2, 2019·Frontiers in Immunology·Frances L EvansDenise C Fitzgerald
Sep 25, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Jay AminClive Holmes
Mar 13, 2017·Journal of Neuroinflammation·Rebecca MontacuteStuart McRae Allan
Dec 18, 2018·Frontiers in Aging Neuroscience·Brandalyn C RiedelUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 6, 2018·International Journal of Alzheimer's Disease·Corona SolanaRafael Solana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.