Altered Macular Microvasculature in Neuromyelitis Optica Spectrum Disorders

American Journal of Ophthalmology
William Robert KwapongFan Lu

Abstract

To evaluate macular microvascular changes in neuromyelitis optica spectrum disorders (NMOSD) by using optical coherence tomography angiography (OCT-A) and investigate their correlations with neuroaxonal structural damage evaluated with spectral-domain OCT (SD-OCT). Cross-sectional study. Twenty eyes of 20 patients with NMOSD and 21 eyes from 21 healthy controls were enrolled. OCT-A was used to obtain microvascular network images of the whole, superficial, and deep retinal capillary plexuses (WRCP, SRCP, and DRCP) in a 3-mm-diameter area around the macula. SD-OCT was used to obtain the intraretinal thickness. Custom automated algorithms quantified the thickness of the intraretinal layers as well as microvascular density of the retinal capillary layers. NMOSD patients showed significantly decreased microvascular density in both SRCP and DRCP (P < .05) compared to controls. The decreased microvascular density in SRCP and DRCP significantly correlated with the frequency of optic neuritis attack (P < .05). Both SRCP and DRCP microvascular density significantly correlated (P < .05) with retinal nerve fiber layer and ganglion cell layer with inner plexiform layer. SRCP microvascular density moderately correlated with visual acuity, wh...Continue Reading

Citations

May 3, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
Oct 20, 2018·Current Neurology and Neuroscience Reports·Adam Wylęgała
Jun 25, 2020·Neurology. Neuroimmunology and Neuroinflammation·Seyedamirhosein MotamediAlexander U Brandt
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Rui LinZi-Bing Jin
Dec 14, 2019·Therapeutic Advances in Chronic Disease·Timothy E YapM Francesca Cordeiro
Jul 1, 2020·Multiple Sclerosis and Related Disorders·William Robert KwapongXiaozheng Liu
Jul 15, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Lilian AlyBenjamin Knier
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jian YuMin Wang

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