Altered malondialdehyde, protein carbonyl and sialic acid levels in seminal plasma of microscopically abnormal semen

Andrologia
A SaraniyaV Shivagourou

Abstract

Microscopically abnormal (n = 26) semen showed significantly higher levels of malondialdehyde (MDA), protein carbonyl (PC) and protein-bound sialic acid (SA) in seminal plasma as compared with normal semen (n = 24). The percentage of nonmotile spermatozoa showed significant (P < 0.01) positive correlation with MDA (r = 0.5) and PC (r = 0.49). Sperm counts showed a significant negative correlation with MDA (r = -0.63, P < 0.001) level of seminal plasma. SA correlated (r = 0.56, P < 0.01) with MDA. The receiver operating characteristic (ROC) curve of MDA and SA showed that MDA of 3.15 micromol l(-1) and SA of 3.85 micromol l(-1) were optimum cut-off limits to discriminate abnormal semen from normal. In conclusion, high SA might be a protective response against prevailed oxidative stress in abnormal semen. Seminal plasma MDA and SA may act as potential markers of abnormal semen.

References

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Jan 1, 1994·Reproduction, Fertility, and Development·R J Aitken
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Citations

Nov 16, 2010·Asian Journal of Andrology·Ralf R Henkel
Mar 12, 2013·Environmental Toxicology and Pharmacology·I A AdedaraE O Farombi
Dec 22, 2009·Reproductive Biomedicine Online·Francesco M LanzafameAldo E Calogero
Mar 20, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Moustafa A A El-TaiebMichael Marberger
Jun 24, 2011·International Journal of Andrology·S La VigneraA E Calogero
Sep 28, 2013·Journal of Medical Microbiology·Sandro La VigneraAldo E Calogero
Jul 16, 2013·Journal of Reproductive Immunology·Sandro La VigneraAldo E Calogero
Feb 27, 2017·Theriogenology·Agnieszka MostekAndrzej Ciereszko
Jan 15, 2019·Andrologia·Shabir Ahmad LoneHanuman Prasad Yadav

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