PMID: 8948476Nov 13, 1996Paper

Altered membrane phospholipid organization and erythrophagocytosis in E beta-thalassemia

Biochimica Et Biophysica Acta
P T Srinivasan, J Basu

Abstract

The underlying cause behind the accelerated destruction of erythrocytes in the bone marrow and in the peripheral circulation, accompanying the beta-thalassemic syndromes is still not clearly understood. The present investigation demonstrates that increased phagocytosis of erythrocytes in E beta-thalassemia is inhibited by the presence of phosphatidylserine (PS) vesicles, suggesting a PS-'PS-receptor' type of interaction in premature recognition of these erythrocytes by macrophages. Increased exposure of both aminophospholipids phosphatidylethanolamine (PE) and PS was demonstrated by fluorescamine labeling and annexin binding, respectively. The slower rate of translocation of PS across the bilayer suggested that this contributed towards the increased exposure of PS in E beta-thalassemic erythrocytes.

References

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Citations

Sep 5, 2003·International Journal of Hematology·Vichai AtichartakarnKatcharin Aryurachai
Jan 22, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·D BratosinJ Montreuil
Aug 14, 1999·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Jan 14, 2004·British Journal of Haematology·Tinku Banerjee, Frans A Kuypers

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