Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis

Metabolomics : Official Journal of the Metabolomic Society
Chen ChenDaniel Raftery

Abstract

Metabolomics technologies enable the identification of putative biomarkers for numerous diseases; however, the influence of confounding factors on metabolite levels poses a major challenge in moving forward with such metabolites for pre-clinical or clinical applications. To address this challenge, we analyzed metabolomics data from a colorectal cancer (CRC) study, and used seemingly unrelated regression (SUR) to account for the effects of confounding factors including gender, BMI, age, alcohol use, and smoking. A SUR model based on 113 serum metabolites quantified using targeted mass spectrometry, identified 20 metabolites that differentiated CRC patients (n = 36), patients with polyp (n = 39), and healthy subjects (n = 83). Models built using different groups of biologically related metabolites achieved improved differentiation and were significant for 26 out of 29 groups. Furthermore, the networks of correlated metabolites constructed for all groups of metabolites using the ParCorA algorithm, before or after application of the SUR model, showed significant alterations for CRC and polyp patients relative to healthy controls. The results showed that demographic covariates, such as gender, BMI, BMI2, and smoking status, exhibit ...Continue Reading

References

Feb 24, 1956·Science·O WARBURG
Oct 14, 2004·Bioinformatics·Juliane Schäfer, Korbinian Strimmer
Aug 15, 2009·Journal of Proteome Research·Yunping QiuWei Jia
Jun 24, 2010·Trends in Biochemical Sciences·David R Wise, Craig B Thompson
May 11, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·David P TaylorRandall W Burt
Jan 13, 2012·Cell Death & Disease·C Muñoz-PinedoJ-E Ricci
Mar 24, 2012·Cancer Cell·Patrick S Ward, Craig B Thompson
Jun 15, 2012·International Journal of Cancer. Journal International Du Cancer·Shawn A RitchieDayan B Goodenowe
Jul 14, 2012·PloS One·Shin NishiumiMasaru Yoshida
May 17, 2013·Journal of Proteome Research·Binbin TanWei Jia
Dec 7, 2013·BioMed Research International·Roman EisnerRichard N Fedorak
Aug 16, 2014·Journal of Proteome Research·Jiangjiang ZhuDaniel Raftery
Jun 16, 2016·JAMA : the Journal of the American Medical Association·Jennifer S LinEvelyn P Whitlock
Jul 8, 2016·Science Advances·Ralph J DeBerardinis, Navdeep S Chandel
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Feb 14, 2018·G3 : Genes - Genomes - Genetics·Duke PauliMichael A Gore
Jan 11, 2020·BMC Bioinformatics·Takoua Jendoubi, Timothy M D Ebbels
Jan 28, 2019·Lipids in Health and Disease·Alicja PakietAdriana Mika
Jun 10, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jiwon BaekHyeon Chang Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Software Mentioned

ParCorA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.