Altered microbiomes in bovine digital dermatitis lesions, and the gut as a pathogen reservoir

PloS One
Martin ZinicolaRodrigo Bicalho

Abstract

Bovine digital dermatitis (DD) is the most important infectious disease associated with lameness in cattle worldwide. Since the disease was first described in 1974, a series of Treponema species concurrent with other microbes have been identified in DD lesions, suggesting a polymicrobial etiology. However, the pathogenesis of DD and the source of the causative microbes remain unclear. Here we characterized the microbiomes of healthy skin and skin lesions in dairy cows affected with different stages of DD and investigated the gut microbiome as a potential reservoir for microbes associated with this disease. Discriminant analysis revealed that the microbiomes of healthy skin, active DD lesions (ulcerative and chronic ulcerative) and inactive DD lesions (healing and chronic proliferative) are completely distinct. Treponema denticola, Treponema maltophilum, Treponema medium, Treponema putidum, Treponema phagedenis and Treponema paraluiscuniculi were all found to be present in greater relative abundance in active DD lesions when compared with healthy skin and inactive DD lesions, and these same Treponema species were nearly ubiquitously present in rumen and fecal microbiomes. The relative abundance of Candidatus Amoebophilus asiatic...Continue Reading

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Datasets Mentioned

BETA
SRR1562236

Methods Mentioned

BETA
biopsy
PCR
electrophoresis
Assay

Software Mentioned

MiSeq Reporter
Fastq
RAST
UCLUST
Casava
Canonical
USEARCH
Quantitative Insights Into Microbial Ecology ( QIIME )
JPM Pro
MG

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